Evidence map›Paper›PMID 28488815›Full record

ArticleJournal of cellular physiology2017

Hypomorphic conditional deletion of E11/Podoplanin reveals a role in osteocyte dendrite elongation.

Katherine A Staines, Behzad Javaheri, Peter Hohenstein, Robert Fleming, Ekele Ikpegbu, Erin Unger, Mark Hopkinson, David J Buttle, Andrew A Pitsillides, Colin Farquharson

Open access · hybridAbstract read
In one paragraph

Article in Journal of cellular physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.2field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. [Role of Piezo mechanosensitive ion channels in the osteoarticular system].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2024
    Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Katherine A StainesRoslin Institute and R(D)SVS, The University of Edinburgh, Easter Bush, Midlothian, UK.ORCID http://orcid.org/0000-0002-8492-9778
Behzad JavaheriComparative Biomedical Sciences, Royal Veterinary College, London, UK.
Peter HohensteinRoslin Institute and R(D)SVS, The University of Edinburgh, Easter Bush, Midlothian, UK.
Robert FlemingRoslin Institute and R(D)SVS, The University of Edinburgh, Easter Bush, Midlothian, UK.
Ekele IkpegbuRoslin Institute and R(D)SVS, The University of Edinburgh, Easter Bush, Midlothian, UK.
Erin UngerRoslin Institute and R(D)SVS, The University of Edinburgh, Easter Bush, Midlothian, UK.
Mark HopkinsonComparative Biomedical Sciences, Royal Veterinary College, London, UK.
David J ButtleDepartment of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK.
Andrew A PitsillidesComparative Biomedical Sciences, Royal Veterinary College, London, UK.
Colin FarquharsonRoslin Institute and R(D)SVS, The University of Edinburgh, Easter Bush, Midlothian, UK.
Roslin Institute · GBRoyal Veterinary College · GBUniversity of Sheffield · GB

Funding

Arthritis Research UK 20413Medical Research Council MR/M010341/1Versus Arthritis 20581
6 · The paper itself

Abstract

The transmembrane glycoprotein E11/Podoplanin (Pdpn) has been implicated in the initial stages of osteocyte differentiation. However, its precise function and regulatory mechanisms are still unknown. Due to the known embryonic lethality induced by global Pdpn deletion, we have herein explored the effect of bone-specific Pdpn knockdown on osteocyte form and function in the post-natal mouse. Extensive skeletal phenotyping of male and female 6-week-old Oc-cre;Pdpn

Indexed as

Cell DifferentiationCell ShapeGene DeletionOsteogenesisAnimalsFemaleGenotypeMaleMembrane GlycoproteinsMice, KnockoutOsteocytesPhenotypePodoplaninSignal TransductionTibiaX-Ray MicrotomographyMembrane GlycoproteinsPdpn protein, mousePodoplanindendriteE11osteoblastsosteocalcinosteocytes

Identifiers

PMID28488815
PMCPMC5575468
OpenAlexW2612086182

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.