Evidence map›Paper›PMID 28488689›Full record

SynthesisEuropean journal of clinical nutrition2017

Effects of vitamin D or its analogues on the mortality of patients with chronic kidney disease: an updated systematic review and meta-analysis.

R J Lu, S M Zhu, F L Tang, X S Zhu, Z D Fan, G L Wang, Y F Jiang, Y Zhang

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in European journal of clinical nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Guideline
  5. Trial
  6. Trial
  7. Review
  8. Review
  9. Vitamin D and Cardiovascular Disease: An Updated Narrative Review.International journal of molecular sciences · 2021
    Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Vitamin D and Cardiovascular Complications of CKD: What's Next?Clinical journal of the American Society of Nephrology : CJASN · 2019
    Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

R J LuDepartment of Pharmacy, The Third People's Hospital of Changzhou, Changzhou, People's Republic of China.
S M ZhuDepartment of Pharmacy, The Third People's Hospital of Changzhou, Changzhou, People's Republic of China.
F L TangDepartment of Pharmacy, The Third People's Hospital of Changzhou, Changzhou, People's Republic of China.
X S ZhuDepartment of Urinary Surgery, The Third People's Hospital of Changzhou, Changzhou, People's Republic of China.
Z D FanDepartment of Pharmacy, The Third People's Hospital of Changzhou, Changzhou, People's Republic of China.
G L WangDepartment of Urinary Surgery, The Third People's Hospital of Changzhou, Changzhou, People's Republic of China.
Y F JiangDepartment of Urinary Surgery, The Third People's Hospital of Changzhou, Changzhou, People's Republic of China.
Y ZhangDepartment of Internal Medicine, The Third People's Hospital of Changzhou, Changzhou, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of this study was to assess whether vitamin D (VD) treatment alters the overall all-cause and cardiovascular mortalities in a chronic kidney disease (CKD) population. We systematically searched PubMed, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials without language restriction, until the publication date of 22 February 2016. All related literatures that compared VD treatment with non-VD treatment and reported the mortality of patients with CKD (including those undergoing dialysis) were identified. Pooled risk ratios (RR) and 95% confidence intervals (CI) were calculated by using the random- and fixed-effects models. Randomised controlled trials (RCTs) that used the intention-to-treat principle and observational studies (OSs) were analysed separately. For this study, 38 studies involving 223 429 patients (17 RCTs, n=1819 and 21 OSs, n=221610) were included. In the OSs, VD treatment was significantly associated with reductions in both all-cause and cardiovascular mortalities; however, such significant association was not found in the RCTs. The existing RCTs do not provide sufficient or precise evidence that VD supplementation affects the mortality of patients with CKD, although subsets of patients that could potentially benefit from VD treatment can be identified by using the existing data from the RCTs. Nevertheless, large-size RCTs are needed in the future to assess any potential differences in survival prospectively.

Indexed as

Dietary SupplementsHumansObservational Studies as TopicRandomized Controlled Trials as TopicRenal DialysisRenal Insufficiency, ChronicVitamin DVitamin D

Identifiers

PMID28488689

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.