SynthesisEuropean journal of clinical nutrition2017
The impact of cholecalciferol supplementation on the systemic inflammatory profile: a systematic review and meta-analysis of high-quality randomized controlled trials.
Synthesis in European journal of clinical nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Pooled it
- Non-skeletal health effects of vitamin D supplementation: A systematic review on findings from meta-analyses summarizing trial data.PloS one · 2017Pooled it
- Potential Modulation of Inflammation and Physical Function by Combined Probiotics, Omega-3 Supplementation and Vitamin D Supplementation in Overweight/Obese Patients with Chronic Low-Grade Inflammation: A Randomized, Placebo-Controlled Trial.International journal of molecular sciences · 2023Trial
- Effect of Vitamin D Supplementation on Inflammatory Biomarkers in School-Aged Children with Attention Deficit Hyperactivity Disorder.International journal of clinical practice · 2022Trial
- Effect of Vitamin D Supplementation on Faecal Microbiota: A Randomised Clinical Trial.Nutrients · 2019Trial
- Thirteen weeks of supplementation of vitamin D and leucine-enriched whey protein nutritional supplement attenuates chronic low-grade inflammation in sarcopenic older adults: the PROVIDE study.Aging clinical and experimental research · 2019Trial
- Effects of a simple home exercise program and vitamin D supplementation on health-related quality of life after a hip fracture: a randomized controlled trial.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2019Trial
- The Effect of Vitamin D Supplementation on Hepcidin, Iron Status, and Inflammation in Pregnant Women in the United Kingdom.Nutrients · 2019Trial
- Vitamin D Enhancement of Adipose Biology: Implications on Obesity-Associated Cardiometabolic Diseases.Nutrients · 2025Review
- Longitudinal associations between vitamin D status and biomarkers of inflammation in a pan-European cohort of children and adolescents.European journal of nutrition · 2024Article
- Maternal prenatal, with or without postpartum, vitamin D3 supplementation does not improve maternal iron status at delivery or infant iron status at 6 months of age: secondary analysis of a randomised controlled trial.BMJ nutrition, prevention & health · 2023Article
- Vitamin D and cardiovascular disease risk. A literature overview.Molecular biology reports · 2022Review
- The role of inflammation and the possibilities of inflammation reduction to prevent cardiovascular events.European heart journal open · 2022Review
- Analysis of the Seasonal Fluctuation of γδ T Cells and Its Potential Relation with Vitamin DCells · 2022Article
- Impact of Vitamin D Supplementation on Inflammatory Markers' Levels in Obese Patients.Current issues in molecular biology · 2021Article
- Prevalence of obesity and hypovitaminosis D in elderly with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).Clinical nutrition ESPEN · 2020Article
- Correlation between premorbid IL-6 levels and COVID-19 mortality: Potential role for Vitamin D.International immunopharmacology · 2020Article
- Consensus statement from 2Reviews in endocrine & metabolic disorders · 2020Article
- Effects of Vitamin D Supplementation and Seasonality on Circulating Cytokines in Adolescents: Analysis of Data From a Feasibility Trial in Mongolia.Frontiers in nutrition · 2019Article
- Effects of Inflammation on Biomarkers of Vitamin A Status among a Cohort of Bolivian Infants.Nutrients · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Causal links between vitamin D status [25(OH)D] and systemic inflammation were examined through a systematic review of randomized controlled trials (RCTs). Selected RCTs were ⩾12 weeks, conducted in adults free of acute inflammatory disease, and of high-quality (Jadad score ⩾3). Of 14 studies that met our criteria, 9 studies (15 study arms) permitted extraction of data. There was no effect on the weighted mean difference (WMD) of IL-6 (WMD (95% confidence interval)=0.1, (-0.166, 0.366) pg/ml, P=0.462) or C-reactive protein (CRP) (WMD=-0.324, (-1.007, 0.359) mg/l, P=0.352). Subgroup analyses of trials achieving ⩾80 nmol/l indicated a trend for lower CRP (WMD=-0.834, (-1.726, 0.058) mg/l, P=0.067), however heterogeneity was significant (I
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.