Evidence map›Paper›PMID 28488329›Full record

ArticleGenes, brain, and behavior2017

Phosphodiesterase-1b deletion confers depression-like behavioral resistance separate from stress-related effects in mice.

J R Hufgard, M T Williams, C V Vorhees

Open access · bronzeAbstract read
In one paragraph

Article in Genes, brain, and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. CaCell reports · 2024
    Article
  2. Circuit-Wide Gene Network Analysis Reveals Sex-Specific Roles for Phosphodiesterase 1b in Cocaine Addiction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

J R HufgardDivision of Neurology, Department of Pediatrics, Cincinnati Children's Research Foundation, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
M T WilliamsDivision of Neurology, Department of Pediatrics, Cincinnati Children's Research Foundation, University of Cincinnati College of Medicine, Cincinnati, OH, USA.ORCID 0000-0001-9841-9683
C V VorheesDivision of Neurology, Department of Pediatrics, Cincinnati Children's Research Foundation, University of Cincinnati College of Medicine, Cincinnati, OH, USA.ORCID 0000-0003-3558-8812
Cincinnati Children's Hospital Medical Center · US

Funding

TRAINING PROGRAM IN TERATOLOGYT32ES007051 · NIEHS · CINCINNATI CHILDRENS HOSP MED CTR · PI VORHEES, CHARLES V · 1985 to 2018
$4.1M
NIEHS NIH HHS T32 ES007051
6 · The paper itself

Abstract

Phosphodiesterase-1b (Pde1b) is highly expressed in striatum, dentate gyrus, CA3 and substantia nigra. In a new Floxed Pde1b × Cre

Indexed as

PhenotypeAnimalsBrainCyclic Nucleotide Phosphodiesterases, Type 1DepressionFemaleMaleMiceMice, Inbred C57BLStress, PsychologicalCyclic Nucleotide Phosphodiesterases, Type 1Pde1b protein, mouseCritical perioddentate gyrusforced swim testphosphodiesterase-1bstriatumtail suspension test

Identifiers

PMID28488329
PMCPMC5677534
OpenAlexW2613998332

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.