ArticleMagnetic resonance in medicine2018
Acute pressure changes in the brain are correlated with MR elastography stiffness measurements: initial feasibility in an in vivo large animal model.
Article in Magnetic resonance in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 45 citations in OpenAlex.
- Repeatability of Magnetic Resonance Elastography-Derived Mechanical Parameters in Intracranial Meningiomas.Journal of magnetic resonance imaging : JMRI · 2025Article
- The Networking Brain: How Extracellular Matrix, Cellular Networks, and Vasculature Shape the In Vivo Mechanical Properties of the Brain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Acute effects of high-intensity exercise on brain mechanical properties and cognitive function.Brain imaging and behavior · 2024Article
- Evaluation of MR Elastography as a Noninvasive Diagnostic Test for Spontaneous Intracranial Hypotension.AJNR. American journal of neuroradiology · 2024Article
- Feasibility of assessing non-invasive intracranial compliance using FSI simulation-based and MR elastography-based brain stiffness.Scientific reports · 2024Article
- Functional MR elastography measures visual cortex stiffening proportional to visual contrast intensity in regions of activation.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Clinical application of magnetic resonance elastography in pediatric neurological disorders.Pediatric radiology · 2023Review
- Stiffness pulsation of the human brain detected by non-invasive time-harmonic elastography.Frontiers in bioengineering and biotechnology · 2023Article
- Features of Idiopathic Intracranial Hypertension on MRI With MR Elastography: Prospective Comparison With Control Individuals and Assessment of Postintervention Changes.AJR. American journal of roentgenology · 2022Article
- Magnetic resonance elastography in normal pressure hydrocephalus-a scoping review.Neurosurgical review · 2022Article
- Noninvasive detection of elevated ICP using spontaneous tympanic membrane pulsation.Scientific reports · 2021Article
- Brain stiffness following recovery in a patient with an episode of low-pressure hydrocephalus: case report.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- Impact of initial midline shift in glioblastoma on survival.Neurosurgical review · 2021Article
- Harnessing brain waves: a review of brain magnetic resonance elastography for clinicians and scientists entering the field.The British journal of radiology · 2021Review
- Real-Time Multifrequency MR Elastography of the Human Brain Reveals Rapid Changes in Viscoelasticity in Response to the Valsalva Maneuver.Frontiers in bioengineering and biotechnology · 2021Article
- Standard-space atlas of the viscoelastic properties of the human brain.Human brain mapping · 2020Article
- Compression stiffening of fibrous networks with stiff inclusions.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Cardiac-gated steady-state multifrequency magnetic resonance elastography of the brain: Effect of cerebral arterial pulsation on brain viscoelasticity.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Article
- Mechanical regulation of oligodendrocyte biology.Neuroscience letters · 2020Review
- Hypercapnia increases brain viscoelasticity.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
purposeThe homeostasis of intracranial pressure (ICP) is of paramount importance for maintaining normal brain function. A noninvasive technique capable of making direct measurements of ICP currently does not exist. MR elastography (MRE) is capable of noninvasively measuring brain tissue stiffness in vivo, and may act as a surrogate to measure ICP. The objective of this study was to investigate the impact of changing ICP on brain stiffness using MRE in a swine model.
methodsBaseline MRE measurements were obtained, and then catheters were surgically placed into the left and right lateral ventricles of three animals. ICP was systematically increased over the range of 0 to 55 millimeters mercury (mmHg), and stiffness measurements were made using brain MRE at vibration frequencies of 60 hertz (Hz), 90 Hz, 120 Hz, and 150 Hz.
resultsA significant linear correlation between stiffness and ICP in the cross-subject comparison was observed for all tested vibrational frequencies (P ≤ 0.01). The 120 Hz (0.030 ± 0.004 kilopascal (kPa)/mmHg, P < 0.0001) and 150 Hz (0.031 ± 0.008 kPa/mmHg, P = 0.01) vibrational frequencies had nearly identical slopes, which were approximately two- to three-fold higher than the 90 Hz (0.017 ± 0.002 kPa/mmHg, P < 0.0001) and 60 Hz (0.009 ± 0.002 kPa/mmHg, P = 0.001) slopes, respectively.
conclusionIn this study, MRE demonstrated the potential for noninvasive measurement of changes in ICP. Magn Reson Med 79:1043-1051, 2018. © 2017 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
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