Evidence map›Paper›PMID 28488249›Full record

ArticleBiological trace element research2018

Uptake and Utilization of Selenium from Selenoprotein P.

Sumangala Shetty, John R Marsicano, Paul R Copeland

Abstract read
In one paragraph

Article in Biological trace element research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. International journal of molecular sciences · 2022
    Article
  5. Review
  6. Article
  7. Article
  8. Selenium at theFrontiers in neuroscience · 2021
    Review
  9. Article
  10. Review
  11. From Selenium Absorption to Selenoprotein Degradation.Biological trace element research · 2019
    Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Sumangala ShettyDepartment of Biochemistry and Molecular Biology, Rutgers Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ, 08854, USA.
John R MarsicanoDepartment of Biochemistry and Molecular Biology, Rutgers Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ, 08854, USA.
Paul R CopelandDepartment of Biochemistry and Molecular Biology, Rutgers Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ, 08854, USA. paul.copeland@rutgers.edu.ORCID http://orcid.org/0000-0003-3343-0587
Rutgers, The State University of New Jersey · US

Funding

Functional Analysis of SBP2 and Selenocysteine IncorporationR01GM077073 · NIGMS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI COPELAND, PAUL R · 2006 to 2022
$5.5M
Development of a zebrafish model for selenoprotein synthesis and functionR21HD083616 · NICHD · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI COPELAND, PAUL R · 2016 to 2017
$428k
NICHD NIH HHS R21 HD083616NIGMS NIH HHS R01 GM077073
6 · The paper itself

Abstract

Selenoprotein P (SELENOP) is a serum glycoprotein that is required for proper selenium distribution in mammals, particularly in supplying selenium to the brain and testes. As the sole mechanism for providing essential selenium to developing spermatozoa, SELENOP metabolism is central to male fertility in all mammals. In addition, this process is important for proper brain function, especially under conditions of limited dietary selenium. Several specific and nonspecific mechanisms for SELENOP uptake in target tissues have been described, but the utilization of SELENOP as a source of selenium for intracellular selenoprotein production has not been systematically characterized. In this report, we examine the process of SELENOP uptake using a robust selenium uptake assay that measures selenium utilization in cells fed

Indexed as

AnimalsDietary ExposureHEK293 CellsHeLa CellsHep G2 CellsHumansSeleniumSelenoprotein PTumor Cells, CulturedZebrafishSeleniumSelenoprotein POxidationSeleniumSelenocysteineSelenoprotein P

Identifiers

PMID28488249
PMCPMC5680150
OpenAlexW2612838704

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.