Evidence map›Paper›PMID 28488235›Full record

ReviewStem cell reviews and reports2017

Emulating Host-Microbiome Ecosystem of Human Gastrointestinal Tract in Vitro.

Gun-Seok Park, Min Hee Park, Woojung Shin, Connie Zhao, Sameer Sheikh, So Jung Oh, Hyun Jung Kim

Abstract readReview
PubMed Publisher
In one paragraph

Review in Stem cell reviews and reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 71 citations in OpenAlex.

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  18. Effects of simulated digestion on black chokeberry (Journal of food science and technology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Gun-Seok ParkDepartment of Biomedical Engineering, The University of Texas at Austin, 107 W. Dean Keeton St. BME 4.202C, Austin, TX, 78712, USA.
Min Hee ParkDepartment of Biomedical Engineering, The University of Texas at Austin, 107 W. Dean Keeton St. BME 4.202C, Austin, TX, 78712, USA.
Woojung ShinDepartment of Biomedical Engineering, The University of Texas at Austin, 107 W. Dean Keeton St. BME 4.202C, Austin, TX, 78712, USA.
Connie ZhaoDepartment of Biomedical Engineering, The University of Texas at Austin, 107 W. Dean Keeton St. BME 4.202C, Austin, TX, 78712, USA.
Sameer SheikhDepartment of Biomedical Engineering, The University of Texas at Austin, 107 W. Dean Keeton St. BME 4.202C, Austin, TX, 78712, USA.
So Jung OhCollege of Natural Sciences, The University of Texas at Austin, Austin, TX, 78712, USA.
Hyun Jung KimDepartment of Biomedical Engineering, The University of Texas at Austin, 107 W. Dean Keeton St. BME 4.202C, Austin, TX, 78712, USA. hyunjung.kim@utexas.edu.ORCID 0000-0001-5342-2870
The University of Texas at Austin · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The human gut microbiome performs prodigious physiological functions such as production of microbial metabolites, modulation of nutrient digestion and drug metabolism, control of immune system, and prevention of infection. Paradoxically, gut microbiome can also negatively orchestrate the host responses in diseases or chronic disorders, suggesting that the regulated and balanced host-gut microbiome crosstalk is a salient prerequisite in gastrointestinal physiology. To understand the pathophysiological role of host-microbiome crosstalk, it is critical to recreate in vivo relevant models of the host-gut microbiome ecosystem in human. However, controlling the multi-species microbial communities and their uncontrolled growth has remained a notable technical challenge. Furthermore, conventional two-dimensional (2D) or 3D culture systems do not recapitulate multicellular microarchitectures, mechanical dynamics, and tissue-specific functions. Here, we review recent advances and current pitfalls of in vitro and ex vivo models that display human GI functions. We also discuss how the disruptive technologies such as 3D organoids or a human organ-on-a-chip microphysiological system can contribute to better emulate host-gut microbiome crosstalks in health and disease. Finally, the medical and pharmaceutical significance of the gut microbiome-based personalized interventions is underlined as a future perspective.

Indexed as

EcosystemGastrointestinal MicrobiomeGastrointestinal TractHumansCo-cultureGut microbiomeIn vitro modelOrganoidsOrgan-on-a-chip

Identifiers

PMID28488235
OpenAlexW2613079570

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.