ArticleFrontiers of medicine2017
Triage for management of cervical high-grade squamous intraepithelial lesion patients with positive margin by conization: a retrospective analysis.
Article in Frontiers of medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- Evaluation of HPV E6/E7 mRNA in predicting recurrence after Leep in cervical intraepithelial neoplasia: A study of negative findings.PloS one · 2026Article
- The rationality of negative margin criteria for conization in early cervical cancer - a cohort study.BMC cancer · 2025Article
- Prediction Models of Microinvasive Cervical Cancer in High-Grade Squamous Intraepithelial Lesion Treatment by Loop Electrosurgical Excision Procedure.Risk management and healthcare policy · 2025Article
- Risk factors for residual lesions after total hysterectomy in patients with high-grade cervical intraepithelial neoplasia.BMC women's health · 2024Article
- Are "additional cuts" effective for positive margins in cervical conization? It varies according to the doctor.World journal of surgical oncology · 2023Article
- Article
- A predictive model for residual lesions after LEEP surgery in CIN III patients.Frontiers in medicine · 2023Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study is to guide a triage for the management of cervical high-grade squamous intraepithelial lesion (HSIL) patients with positive margin by conization. Clinico-pathological data of HSIL patients with positive margin by conization were retrospectively collected from January 2009 to December 2014. All patients underwent secondary conization or hysterectomy within 6 months. The rate of residual lesion was calculated, and the factors associated with residual lesion were analyzed by univariate and multivariate analyses. Among a total of 119 patients, 56 (47.06%) patients presented residual HSIL in their subsequent surgical specimens, including 4 cases of invasive cervical carcinoma (3 stage IA1 and 1 stage IA2 patients). Univariate analysis showed that patient age > 35 years (P = 0.005), menopausal period > 5 years (P = 0.0035), and multiple-quadrant involvement (P = 0.001) were significantly correlated with residual disease; however, multivariate analysis revealed that multiple-quadrant involvement (P = 0.001; OR, 3.701; 95%CI, 1.496-9.154) was an independent risk factor for residual disease. Nearly half of HSIL patients with positive margin by conization were disease-free in subsequent surgical specimens, and those with multiple positive margins may consider reconization or re-assessment.
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