Evidence map›Paper›PMID 28488184›Full record

ArticleThe European journal of health economics : HEPAC : health economics in prevention and care2018

Costs of illness of multiple sclerosis in Sweden: a population-based register study of people of working age.

Hanna Gyllensten, Michael Wiberg, Kristina Alexanderson, Anders Norlund, Emilie Friberg, Jan Hillert, Olivia Ernstsson, Petter Tinghög

Abstract read
In one paragraph

Article in The European journal of health economics : HEPAC : health economics in prevention and care, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. The economic impact of comorbidity in multiple sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
    Article
  5. Polypharmacy and multiple sclerosis: A population-based study.Multiple sclerosis (Houndmills, Basingstoke, England) · 2023
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Comorbid disease burden among MS patients 1968-2012: A Swedish register-based cohort study.Multiple sclerosis (Houndmills, Basingstoke, England) · 2021
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Cognitive function predicts work disability among multiple sclerosis patients.Multiple sclerosis journal - experimental, translational and clinical
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hanna GyllenstenDepartment of Clinical Neuroscience, Karolinska Institutet, Berzelius Väg 3, Floor 6, SE-171 77, Stockholm, Sweden. hanna.gyllensten@ki.se.ORCID http://orcid.org/0000-0001-6890-5162
Michael WibergDepartment of Clinical Neuroscience, Karolinska Institutet, Berzelius Väg 3, Floor 6, SE-171 77, Stockholm, Sweden.
Kristina AlexandersonDepartment of Clinical Neuroscience, Karolinska Institutet, Berzelius Väg 3, Floor 6, SE-171 77, Stockholm, Sweden.
Anders NorlundDepartment of Clinical Neuroscience, Karolinska Institutet, Berzelius Väg 3, Floor 6, SE-171 77, Stockholm, Sweden.
Emilie FribergDepartment of Clinical Neuroscience, Karolinska Institutet, Berzelius Väg 3, Floor 6, SE-171 77, Stockholm, Sweden.
Jan HillertDepartment of Clinical Neuroscience, Karolinska Institutet, Berzelius Väg 3, Floor 6, SE-171 77, Stockholm, Sweden.
Olivia ErnstssonDepartment of Clinical Neuroscience, Karolinska Institutet, Berzelius Väg 3, Floor 6, SE-171 77, Stockholm, Sweden.
Petter TinghögDepartment of Clinical Neuroscience, Karolinska Institutet, Berzelius Väg 3, Floor 6, SE-171 77, Stockholm, Sweden.

Funding

Biogen -the Swedish Research Council for Health, Working Life and Welfare 2007-1762
6 · The paper itself

Abstract

backgroundMultiple sclerosis (MS) causes work disability and healthcare resource use, but little is known about the distribution of the associated costs to society.

objectivesWe estimated the cost of illness (COI) of working-aged individuals with MS, from the societal perspective, overall and in different groups.

methodsA population-based study was conducted, using data linked from several nationwide registers, on 14,077 individuals with MS, aged 20-64 years and living in Sweden. Prevalence-based direct and indirect costs in 2010 were calculated, including costs for prescription drug use, specialized healthcare, sick leave, and disability pension.

resultsThe estimated COI of all the MS patients were SEK 3950 million, of which 75% were indirect costs. MS was the main diagnosis for resource use, causing 38% of healthcare costs and 67% of indirect costs. The distribution of costs was skewed, in which less than 25% of the patients accounted for half the total COI.

conclusionsIndirect costs contributed to approximately 75% of the estimated overall COI of MS patients of working age in Sweden. MS was the main diagnosis for more than half of the estimated COI in this patient group. Further studies are needed to gain knowledge on development of costs over time during the MS disease course.

Indexed as

Cost of IllnessHealth Care CostsSick LeaveAdultFemaleHumansMaleMiddle AgedMultiple SclerosisPensionsSwedenYoung AdultCost of IllnessMultiple sclerosisRegistriesSick leaveSocioeconomic factorsThird-party payers

Identifiers

PMID28488184
PMCPMC5978901

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.