ReviewNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2017
Modulation of Aversive Memory by Adult Hippocampal Neurogenesis.
Review in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 45 citations in OpenAlex.
- Mice produce interneurons in the septum as a response to aversive experiences and antidepressant treatment.Science advances · 2026Article
- Ferroptosis inhibitor UAMC-3203 preserves memory and prevents anxiety-like behavior but worsens aversive learning in diabetic rats after stroke in a randomized preclinical trial.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- Blockade of Dopamine D3 Receptors in the Ventral Tegmental Area Mitigates Fear Memory Generalization.International journal of molecular sciences · 2025Article
- The impact of modafinil on memory and brain oxidative stress: contrasting effects of acute and chronic administration in healthy rats.Metabolic brain disease · 2025Article
- Chronic chemogenetic activation of hippocampal progenitors enhances adult neurogenesis and modulates anxiety-like behavior and fear extinction learning.IBRO neuroscience reports · 2024Article
- Article
- Andrographis paniculata protects against brain hippocampus and cerebellum from mercury chloride induced damage by attenuating oxidative stress.Environmental analysis, health and toxicology · 2022Article
- Global Proteomic Profile of Aluminum-Induced Hippocampal Impairments in Rats: Are Low Doses of Aluminum Really Safe?International journal of molecular sciences · 2022Article
- Adult hippocampal neurogenesis shapes adaptation and improves stress response: a mechanistic and integrative perspective.Molecular psychiatry · 2022Review
- A Baldwin interpretation of adult hippocampal neurogenesis: from functional relevance to physiopathology.Molecular psychiatry · 2022Review
- Abnormal expression of cortical cell cycle regulators underlying anxiety and depressive-like behavior in mice exposed to chronic stress.Frontiers in cellular neuroscience · 2022Article
- Environmental enrichment rescues survival and function of adult-born neurons following early life stress.Molecular psychiatry · 2021Article
- Morris Water Maze and Contextual Fear Conditioning Tasks to Evaluate Cognitive Functions Associated With Adult Hippocampal Neurogenesis.Frontiers in neuroscience · 2021Review
- Functional and Structural Correlates of Impaired Enrichment-Mediated Adult Hippocampal Neurogenesis in a Mouse Model of Prenatal Alcohol Exposure.Brain plasticity (Amsterdam, Netherlands) · 2020Article
- Functional neurogenesis over the years.Behavioural brain research · 2020Review
- Potential Involvement of Adiponectin Signaling in Regulating Physical Exercise-Elicited Hippocampal Neurogenesis and Dendritic Morphology in Stressed Mice.Frontiers in cellular neuroscience · 2020Article
- Know safety, no fear.Neuroscience and biobehavioral reviews · 2020Review
- Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis.Cell metabolism · 2019Article
- Sex specific effects of pre-pubertal stress on hippocampal neurogenesis and behaviour.Translational psychiatry · 2018Article
- Dorsal and ventral hippocampal adult-born neurons contribute to context fear memory.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Adult hippocampal neurogenesis (AHN) occurs in humans and every other mammalian species examined. Evidence that AHN is stimulated by a variety of treatments and behaviors with anxiolytic properties has sparked interest in harnessing AHN to treat anxiety disorders. However, relatively little is known about the mechanisms through which AHN modulates fear and anxiety. In this review, we consider evidence that AHN modulates fear and anxiety by altering the processing of and memory for traumatic experiences. Based on studies of the role of AHN in Pavlovian fear conditioning, we conclude that AHN modulates the consequences of aversive experience by influencing 1) the efficiency of hippocampus-dependent memory acquisition; 2) generalization of hippocampal fear memories; 3) long-term retention of hippocampal aversive memories; and 4) the nonassociative effects of acute aversive experience. The preclinical literature suggests that stimulation of AHN is likely to have therapeutically relevant consequences, including reduced generalization and long-term retention of aversive memories. However, the literature also identifies four caveats that must be addressed if AHN-based therapies are to achieve therapeutic benefits without significant side effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.