SynthesisOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2017
The association between serum uric acid level and the risk of fractures: a systematic review and meta-analysis.
Synthesis in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Recent advances in research on the association between paediatric hyperuricaemia and bone health.Frontiers in endocrinology · 2026Pooled it
- Association between gout and the risk of osteoporosis and fractures: a meta-analysis.Zeitschrift fur Rheumatologie · 2024Pooled it
- Serum uric acid levels in patients with amyotrophic lateral sclerosis: a meta-analysis.Scientific reports · 2018Pooled it
- Influence of serum uric acid on bone and fracture risk in postmenopausal women.Aging clinical and experimental research · 2024Observational
- The relationship between uric acid and bone mineral density in the intermediate stage of CKD 1-3.BMC nephrology · 2024Article
- Interactive effect of serum uric acid and handgrip strength on all-cause mortality among Japanese community-dwelling people.Metabolism open · 2023Article
- Management of patients at very high risk of osteoporotic fractures through sequential treatments.Aging clinical and experimental research · 2022Review
- The relationship between uric acid and total femur bone mineral density in hypertensive and non-hypertensive populations.Frontiers in endocrinology · 2022Article
- Risk of Non-Vertebral Fracture in Gout Compared to Rheumatoid Arthritis.Journal of clinical medicine · 2021Article
- Bone microstructure and volumetric bone mineral density in patients with hyperuricemia with and without psoriasis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020Article
- Serum Uric Acid Status and Its Association with Bone Mineral Density in the Elderly People Aged 60 Years and More.International journal of endocrinology and metabolism · 2019Article
- High serum uric acid level is associated with greater handgrip strength in the aged population.Arthritis research & therapy · 2019Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Controversy has arisen in regarding the association between serum uric acid (UA) and fracture risk. Therefore, we conducted a systemic review and meta-analysis by pooling estimate of five prospective studies (29,110 participants). Results showed that an increased serum UA level is associated with a lower risk of fracture. Numerous studies have demonstrated that high serum UA is a relevant risk factor for a wide variety of diseases, whereas new understanding in serum uric acid follows recent reports demonstrating a protective role of UA in health status. However, the association between serum UA and fracture remains controversial. Therefore, we conduct a systemic review and meta-analysis to determine whether elevated UA level is a protective factor for fracture among prospective studies. We searched for studies published before May 6, 2016, using PubMed, Embase, and Cochrane databases, without any language restriction. The inclusion criteria were published studies investigating the association between UA and fractures. Two authors independently screened the retrieved articles in accordance to the predefined inclusion criteria. We pooled the study-specific relative risk estimates using a random-effect model for comparison of persons whose UA levels were in the top tertile with those in the bottom tertile. Factors that may predict these associations were evaluated in subgroup analysis and meta-regression. The five included prospective studies included 29,110 participants. In random-effect models that included all five included studies, the summary hazard ratios (HRs) (top vs bottom tertiles) were 079 (95% CI, 0.69 to 0.89), without evidence of heterogeneity (P for heterogeneity = 0.458; I
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.