Evidence map›Paper›PMID 28488132›Full record

ReviewCurrent environmental health reports2017

Arsenic and Immune Response to Infection During Pregnancy and Early Life.

Sarah E Attreed, Ana Navas-Acien, Christopher D Heaney

Registry-linked trialAbstract readReview
In one paragraph

Review in Current environmental health reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03930017 (Arsenic and Immune Response to Influenza Vaccination in Pregnant Women and Newborns), which is not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03930017 completednot on this mapstarted 2018, after this paper: background citation

Arsenic and Immune Response to Influenza Vaccination in Pregnant Women and Newborns

TypeobservationalSponsorJohns Hopkins Bloomberg School of Public HealthRan2018 to 2020Enrolled784ConditionsArsenic--Toxicology, Immunologic Disorders Complicating Pregnancy, Vaccine Response Impaired, Micronutrient DeficiencyArmsSeasonal influenza vaccine - VAXIGRIP TETRA influenza vaccine (quadrivalent, split virion, inactivated)
3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Guardians under Siege: Exploring Pollution's Effects on Human Immunity.International journal of molecular sciences · 2024
    Review
  8. Article
  9. Article
  10. Reliability of low mass toenail samples as biomarkers of chronic metal exposure.Journal of exposure science & environmental epidemiology · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Dietary rumen-protected L-arginine orAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2021
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Sarah E AttreedDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Room W7033B, 615 North Wolfe Street, Baltimore, MD, 21205, USA.
Ana Navas-AcienDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Room W7033B, 615 North Wolfe Street, Baltimore, MD, 21205, USA.
Christopher D HeaneyDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Room W7033B, 615 North Wolfe Street, Baltimore, MD, 21205, USA. cheaney1@jhu.edu.
Johns Hopkins University · US

Funding

Arsenic and immune response to influenza vaccination in pregnant women and newbornsR01ES026973 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI HEANEY, CHRISTOPHER D, LABRIQUE, ALAIN BERNARD · 2017 to 2021
$3.6M
Arsenic Exposure, Genetic Determinants and Diabetes Risk in a Family StudyR01ES021367 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI NAVAS-ACIEN, ANA, VAIDYA, DHANANJAY MADHUKAR · 2012 to 2015
$2.4M
Arsenic, Epigenetics and Incident Cardiovascular Disease in American IndiansR01ES025216 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI FALLIN, M DANIELE, NAVAS-ACIEN, ANA · 2015 to 2018
$2.2M
NIEHS NIH HHS R01 ES021367NIEHS NIH HHS R01 ES025216NIEHS NIH HHS R01 ES026973
6 · The paper itself

Abstract

purpose of reviewArsenic, a known carcinogen and developmental toxicant, is a major threat to global health. While the contribution of arsenic exposure to chronic diseases and adverse pregnancy and birth outcomes is recognized, its ability to impair critical functions of humoral and cell-mediated immunity-including the specific mechanisms in humans-is not well understood. Arsenic has been shown to increase risk of infectious diseases that have significant health implications during pregnancy and early life. Here, we review the latest research on the mechanisms of arsenic-related immune response alterations that could underlie arsenic-associated increased risk of infection during the vulnerable periods of pregnancy and early life. RECENT

findingsThe latest evidence points to alteration of antibody production and transplacental transfer as well as failure of T helper cells to produce IL-2 and proliferate. Critical areas for future research include the effects of arsenic exposure during pregnancy and early life on immune responses to natural infection and the immunogenicity and efficacy of vaccines.

Indexed as

Arsenic PoisoningInfectionsPrenatal Exposure Delayed EffectsAnimalsArsenicEnvironmental PollutantsFemaleHumansImmune SystemImmunotoxinsMicePregnancyPregnancy OutcomeArsenicEnvironmental PollutantsImmunotoxinsArsenic exposureChildrenImmune responseImmunotoxicityInfectionNewbornsPregnant women

Identifiers

PMID28488132
PMCPMC5521214
OpenAlexW2614013099

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.