Evidence map›Paper›PMID 28488084›Full record

ArticleThe Journal of membrane biology2017

Loop Diuretics Diminish Hemolysis Induced by α-Hemolysin from Escherichia coli.

Carl Martin Söderström, Steen K Fagerberg, Mette B Brogaard, Jens Leipziger, Marianne Skals, Helle A Praetorius

Abstract read
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In one paragraph

Article in The Journal of membrane biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Carl Martin SöderströmDepartment of Biomedicine, Aarhus University, Ole Worms Alle 3, build 1170, 8000, Aarhus C, Denmark.
Steen K FagerbergDepartment of Biomedicine, Aarhus University, Ole Worms Alle 3, build 1170, 8000, Aarhus C, Denmark.
Mette B BrogaardDepartment of Biomedicine, Aarhus University, Ole Worms Alle 3, build 1170, 8000, Aarhus C, Denmark.
Jens LeipzigerDepartment of Biomedicine, Aarhus University, Ole Worms Alle 3, build 1170, 8000, Aarhus C, Denmark.
Marianne SkalsDepartment of Biomedicine, Aarhus University, Ole Worms Alle 3, build 1170, 8000, Aarhus C, Denmark.
Helle A PraetoriusDepartment of Biomedicine, Aarhus University, Ole Worms Alle 3, build 1170, 8000, Aarhus C, Denmark. hp@biomed.au.dk.
Aarhus University · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Uropathogenic Escherichia coli often produce the virulence factor α-hemolysin (HlyA), and the more severe the infection, the likelier it is to isolate HlyA-producing E. coli from patients. HlyA forms pores upon receptor-independent insertion of the toxin into biological membranes and it has been substantiated that HlyA-induced hemolysis is amplified by toxin-induced ATP release and activation of P2X receptors. Thus, hemolysis inflicted by HlyA is a protracted process involving signal transduction. It consists of early, marked cell shrinkage followed by swelling and eventually lysis. The initially shrinkage is a consequence of a substantial Ca

Indexed as

AnimalsBacterial ProteinsErythrocytesEscherichia coliFurosemideHemolysin ProteinsHemolysisHumansMiceMice, KnockoutPhagocytosisSolute Carrier Family 12, Member 2THP-1 CellsBacterial ProteinsFurosemideHemolysin ProteinsSolute Carrier Family 12, Member 2ErythorcytesEscherrichia coliFurosemideHemolysisNKCC1α-hemolysin

Identifiers

PMID28488084
OpenAlexW2611972697

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.