Evidence map›Paper›PMID 28488049›Full record

ArticleLipids2017

Acute Myelogenous Leukemia Cells Secrete Factors that Stimulate Cellular LDL Uptake via Autocrine and Paracrine Mechanisms.

Hasanuzzaman Bhuiyan, Michèle Masquelier, Loukas Tatidis, Astrid Gruber, Christer Paul, Sigurd Vitols

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lipids, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. The role of cholesterol metabolism in leukemia.Blood science (Baltimore, Md.) · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Hasanuzzaman BhuiyanDepartment of Medicine, Clinical Pharmacology Unit, Karolinska Institute, Karolinska University Hospital, Solna, 17176, Stockholm, Sweden.
Michèle MasquelierDepartment of Medicine, Clinical Pharmacology Unit, Karolinska Institute, Karolinska University Hospital, Solna, 17176, Stockholm, Sweden.
Loukas TatidisDepartment of Medicine, Clinical Pharmacology Unit, Karolinska Institute, Karolinska University Hospital, Solna, 17176, Stockholm, Sweden.
Astrid GruberCentre for Haematology and Regenerative Medicine, Karolinska Institute, Karolinska University Hospital, Solna, 171 76, Stockholm, Sweden.
Christer PaulCentre for Haematology and Regenerative Medicine, Karolinska Institute, Karolinska University Hospital, Huddinge, 141 86, Stockholm, Sweden.
Sigurd VitolsDepartment of Medicine, Clinical Pharmacology Unit, Karolinska Institute, Karolinska University Hospital, Solna, 17176, Stockholm, Sweden. sigurd.vitols@ki.se.
Karolinska Institutet · SEKarolinska University Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Leukemic cells isolated from most patients with acute myelogenous leukemia (AML) have higher low density lipoprotein (LDL) uptake than normal mononuclear blood cells. Little is known, however, about the mechanism behind the elevated LDL uptake. We investigated if AML cells secrete factors that stimulate cellular LDL uptake. Mononuclear blood cells were isolated from peripheral blood from 42 patients with AML at diagnosis. Cellular LDL uptake was determined from the degradation rate of

Indexed as

AdultAgedAged, 80 and overBiological TransportCell Line, TumorCholesterolCytokinesHumansInterleukin-6Interleukin-8Leukemia, Myeloid, AcuteLipoproteins, LDLMiddle AgedReceptors, LDLTumor Cells, CulturedTumor Necrosis Factor-alphaCholesterolCytokinesInterleukin-6Interleukin-8Lipoproteins, LDLReceptors, LDLTumor Necrosis Factor-alphaAcute myelogenous leukemiaCholesterolCytokinesLow density lipoprotein receptor

Identifiers

PMID28488049
PMCPMC5486594
OpenAlexW2613738078

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.