ArticleClinical neuroradiology2018
In-stent Stenosis after p64 Flow Diverter Treatment.
Article in Clinical neuroradiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06201598 (Prospective, Single-Arm, Multicenter Study to Evaluate the Effectiveness and Safety of Endovascular Treatment in Patients With Cerebral Aneurysms Using P64 and P48 Flow-Diverter Stents), which is not on this map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prospective, Single-Arm, Multicenter Study to Evaluate the Effectiveness and Safety of Endovascular Treatment in Patients With Cerebral Aneurysms Using P64 and P48 Flow-Diverter Stents
Who cites it
30 citing papers in PubMed, 54 citations in OpenAlex.
- Defining biomaterial-driven design principles for bioabsorbable flow diverters: current state and perspectives.Bioactive materials · 2027Review
- In-Stent Stenosis After Surface-Modified Versus Uncoated Flow Diversion: a Randomized Trial (Derivo 2 Heal vs Derivo 2).Clinical neuroradiology · 2026Article
- Multicenter study of the safety and effectiveness of intracranial aneurysm treatment with the p64MW-HPC flow modulation device.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026Article
- Ultra-high-resolution imaging of intracranial flow diverters with photon counting CT: A comparative phantom study with flat-panel CT.Scientific reports · 2025Article
- Risk factors for in-stent stenosis after flow-diverter implantation for intracranial aneurysm: a single center analysis of 161 consecutive patients.Acta neurochirurgica · 2025Article
- Article
- Heparin Coating Decreases the Thrombotic Signature of Flow Diverter Stents.Annals of biomedical engineering · 2025Article
- Evaluation of flow diverters for cerebral aneurysm therapy: recommendations for imaging analyses in clinical studies, endorsed by ESMINT, ESNR, OCIN, SILAN, SNIS, and WFITN.Journal of neurointerventional surgery · 2025Article
- Subacute Stent Deformities as an Underlying Reason for Vessel Stenosis after Flow Diversion with the p64 Stent: Review and Discussion of Biologic Mechanisms and Consequences.AJNR. American journal of neuroradiology · 2025Article
- The DERIVO 2 Heal Embolization Device in the Treatment of Ruptured and Unruptured Intracranial Aneurysms: a Retrospective Multicenter Study.Clinical neuroradiology · 2025Article
- Multicenter study of HPC coated p48 and p64 flow diverters for treatment of intracranial aneurysms under dual antiplatelet therapy.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- An increase in flow-diverter oversizing values as an independent risk factor for developing more severe in-stent stenosis. A retrospective single-center study based on flow diversion of supraclinoid internal carotid artery aneurysms.Frontiers in neurology · 2024Article
- Long-term outcomes and dynamic changes of in-stent stenosis after Pipeline embolization device treatment of intracranial aneurysms.Journal of neurointerventional surgery · 2023Article
- Endovascular treatment of unruptured intracranial aneurysms with flow diverters: A retrospective long-term single center analysis.The neuroradiology journal · 2023Article
- Factors associated with in-stent stenosis after cerebral aneurysm embolization using a Pipeline embolization device.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2022Article
- Diversion-p64: results from an international, prospective, multicenter, single-arm post-market study to assess the safety and effectiveness of the p64 flow modulation device.Journal of neurointerventional surgery · 2022Article
- Stent-alone treatment of unruptured vertebral artery fusiform aneurysms: A comparison of flow diverter and conventional stents.Frontiers in neurology · 2022Article
- Tortuosity of parent artery predicts in-stent stenosis after pipeline flow-diverter stenting for internal carotid artery aneurysms.Frontiers in neurology · 2022Article
- Bifurcated Aneurysm Location Predicts In-Stent Stenosis After Neuroform-EZ Stent-Assisted Coiling for Intracranial Aneurysm.Frontiers in neurology · 2022Article
- Treatment of In-Stent Stenosis Following Flow Diversion of Intracranial Aneurysms with Cilostazol and Clopidogrel.Neurointervention · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThere is limited information available on the incidence of in-stent stenosis (ISS) secondary to the use of flow-diverting stents in the intracranial vasculature. We sought to determine the incidence, severity, and clinical course of ISS on angiographic follow-up after treatment of saccular aneurysms with p64.
methodsWe retrospectively reviewed all patients who underwent treatment of a saccular (ruptured and unruptured) intracranial aneurysm with ≥1 p64 between 2011 and 2015. Fusiform aneurysms and dissections were excluded. Aneurysms with prior or concomitant saccular treatment (e. g., coiling, clipping) were included. Extradural targets and aneurysms with parent vessel implants other than p64 were excluded. ISS was assessed on follow-up angiography and defined as <50% (mild), 50-75% (moderate), or >75% (severe).
resultsIn total, 205 patients (147 female, 71.7%; median age 57 years), with 223 saccular aneurysms were treated with p64 and had at least 9 months of digital subtraction angiography (DSA) follow-up completed. There was no DSA follow-up available in 8 patients. ISS of any degree at any time was recognized in 65/223 (29.1%) of all target aneurysms. The maximal degree of lumen loss was <50% in 40 lesions (17.9%), 50-75% in 19 lesions (8.5%), and >75% in 6 lesions (2.7%). ISS did not cause a focal neurological deficit in any patient. No progression from stenosis to occlusion was observed. Balloon angioplasty was performed in 1 lesion and was well tolerated. In 56 lesions (84.8%), a significant reduction of ISS occurred spontaneously, 2 mild stenoses remained stable, and for 6 lesions the long-term follow-up is pending.
conclusionTreatment with p64 is associated with an overall rate of 8.5% moderate ISS (50-75%) and 2.7% severe ISS (>75%), which is comparable with the rate of ISS reported in the literature for other flow diverting stents. There is a tendency for ISS to spontaneously improve over time.
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