Evidence map›Paper›PMID 28488023›Full record

ArticlePflugers Archiv : European journal of physiology2017

Glucose enhances rotavirus enterotoxin-induced intestinal chloride secretion.

Liangjie Yin, Rejeesh Menon, Reshu Gupta, Lauren Vaught, Paul Okunieff, Sadasivan Vidyasagar

Abstract read
PubMed Publisher
In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

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  5. The CaActa pharmaceutica Sinica. B · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Liangjie YinDepartment of Radiation Oncology, University of Florida Health Cancer Center, Cancer and Genomic Research Complex, 2033 Mowry Rd., Box 103633, Gainesville, FL, 32610, USA.
Rejeesh MenonDepartment of Radiation Oncology, University of Florida Health Cancer Center, Cancer and Genomic Research Complex, 2033 Mowry Rd., Box 103633, Gainesville, FL, 32610, USA.
Reshu GuptaDepartment of Radiation Oncology, University of Florida Health Cancer Center, Cancer and Genomic Research Complex, 2033 Mowry Rd., Box 103633, Gainesville, FL, 32610, USA.
Lauren VaughtDepartment of Radiation Oncology, University of Florida Health Cancer Center, Cancer and Genomic Research Complex, 2033 Mowry Rd., Box 103633, Gainesville, FL, 32610, USA.
Paul OkunieffDepartment of Radiation Oncology, University of Florida Health Cancer Center, Cancer and Genomic Research Complex, 2033 Mowry Rd., Box 103633, Gainesville, FL, 32610, USA.
Sadasivan VidyasagarDepartment of Radiation Oncology, University of Florida Health Cancer Center, Cancer and Genomic Research Complex, 2033 Mowry Rd., Box 103633, Gainesville, FL, 32610, USA. vidyasagar@ufl.edu.
University of Florida Health · USUF Health Cancer Center

Funding

Entrinsic Health Solutions AGR00003327Entrinsic Health Solutions P0001295National Space Biomedical Research Institute NCC 9-58National Space Biomedical Research Institute RE02901
6 · The paper itself

Abstract

Rotavirus causes severe diarrhea in small children and is typically treated using glucose-containing oral rehydration solutions; however, glucose may have a detrimental impact on these patients, because it increases chloride secretion and presumably water loss. The rotavirus enterotoxin nonstructural protein 4 (NSP4) directly inhibits glucose-mediated sodium absorption. We examined the effects of NSP4 and glucose on sodium and chloride transport in mouse small intestines and Caco-2 cells. Mouse small intestines and Caco-2 cells were incubated with NSP4

Indexed as

AnimalsAnoctamin-1Biological TransportCaco-2 CellsCalciumCell Line, TumorChloridesEnterotoxinsGlucoseGlycoproteinsHumansIntestinal MucosaIntestinesMaleMiceRotavirusAnoctamin-1CalciumChloridesEnterotoxinsGlucoseGlycoproteinsNS28 protein, rotavirusSodiumSodium-Glucose Transporter 1Toxins, BiologicalViral Nonstructural ProteinsAno1NHE3NSP4RotavirusSGLT1

Identifiers

PMID28488023
OpenAlexW2613464874

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.