ArticleMolecular medicine reports2017
MALAT1 participates in ultraviolet B-induced photo-aging via regulation of the ERK/MAPK signaling pathway.
Article in Molecular medicine reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- SLC30A4-AS1 Mediates the Senescence of Periodontal Ligament Stem Cells in Inflammatory Environments via the Alternative Splicing of TP53BP1.Cell proliferation · 2025Article
- Exosomes derived stem cells as a modern therapeutic approach for skin rejuvenation and hair regrowth.Regenerative therapy · 2024Review
- Role of non‑coding RNAs in UV‑induced radiation effects (Review).Experimental and therapeutic medicine · 2024Review
- Deconstructing the role of MALAT1 in MAPK-signaling in melanoma: insights from antisense oligonucleotide treatment.Oncotarget · 2023Article
- Exploring the role of mitochondria transfer/transplant and their long-non-coding RNAs in regenerative therapies for skin aging.Mitochondrion · 2023Article
- Emerging role of long non-coding RNA MALAT1 related signaling pathways in the pathogenesis of lung disease.Frontiers in cell and developmental biology · 2023Review
- Non-coding RNAs in photoaging-related mechanisms: a new paradigm in skin health.Biogerontology · 2022Review
- Inhibitory Effect of Seawater Pearl Hydrolysate on UVA-Induced Photoaging of Human Skin Fibroblasts.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- The role of LncRNA MALAT-1 and MiRNA-9 in Psoriasis.Biochemistry and biophysics reports · 2021Article
- mascRNA and its parent lncRNA MALAT1 promote proliferation and metastasis of hepatocellular carcinoma cells by activating ERK/MAPK signaling pathway.Cell death discovery · 2021Article
- Analysis of the regulation of metastasis-associated lung adenocarcinoma transcript 1 on the biological behavior of breast cancer.Translational cancer research · 2021Article
- Ursodeoxycholic Acid May Inhibit Environmental Aging-Associated Hyperpigmentation.Antioxidants (Basel, Switzerland) · 2021Article
- Therapeutic Effect of Seawater Pearl Powder on UV-Induced Photoaging in Mouse Skin.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Long non-coding RNAs in cutaneous biology and keratinocyte carcinomas.Cellular and molecular life sciences : CMLS · 2020Review
- Role of non-coding-RNAs in response to environmental stressors and consequences on human health.Redox biology · 2020Review
- Signature changes in the expressions of protein-coding genes, lncRNAs, and repeat elements in early and late cellular senescence.Turkish journal of biology = Turk biyoloji dergisi · 2020Article
- New Insights Into the Skin Microbial Communities and Skin Aging.Frontiers in microbiology · 2020Article
- High Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1) Expression Promotes Proliferation, Migration, and Invasion of Non-Small Cell Lung Cancer via ERK/Mitogen-Activated Protein Kinase (MAPK) Signaling Pathway.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- LncRNAs Regulatory Networks in Cellular Senescence.International journal of molecular sciences · 2019Review
- Overexpression of MALAT1 Relates to Lung Injury through Sponging miR-425 and Promoting Cell Apoptosis during ARDS.Canadian respiratory journal · 2019Article
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14 authors.
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Abstract
Long non-coding RNA (lncRNA), transcripts of >200 bp in length that do not appear to exhibit any coding capacity, are important in the occurrence and development of cancer, cardiovascular and neurological diseases. However, effects of lncRNAs on photo‑aging remain to be elucidated. To explore the potential effects of the lncRNA metastasis‑associated lung adenocarcinoma transcript 1 (MALAT1) on photo‑aging in fibroblasts, MALAT1 expression was silenced in fibroblasts using small interference RNA. Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) was used to examine MALAT1 expression in normal and silenced fibroblasts following irradiation with 60 mJ/cm2 ultraviolet B (UVB) and an ELISA assay was used to identify matrix metalloproteinase‑1 (MMP‑1) content in the cellular supernatant. A β-galactosidase kit was applied to measure the number of senescent cells and a western blot assay was used to detect extracellular signal‑regulated kinase (ERK), c‑Jun N‑terminal kinase (JNK) and p38 phosphorylation levels. RT‑qPCR was additionally used to detect changes in MALAT1 expression following suppression of UVB‑induced reactive oxygen species (ROS) generation with N‑acetyl‑L‑cysteine (NAC). Fibroblasts irradiated with 60 mJ/cm2 UVB demonstrated increased MALAT1 expression, MMP‑1 secretory volume and number of senescent cells, and greater levels of ERK, p38 and JNK phosphorylation. Following silencing of MALAT1 expression in photo‑aged fibroblasts, decreases were observed in MMP‑1 secretory volume, number of senescent cells and phosphorylation levels of ERK. NAC reduced ROS content, however, it did not affect MALAT1 expression. Therefore, it was concluded that MALAT1 may participate in UVB‑induced photo‑aging via regulation of the ERK/mitogen‑activated protein kinase signaling pathway and UVB‑induced MALAT1 expression is independent of ROS generation.
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