Evidence map›Paper›PMID 28487899›Full record

ArticleAfrican journal of traditional, complementary, and alternative medicines : AJTCAM2016

ASIATIC ACID INFLUENCES GLUCOSE HOMEOSTASIS IN

Mavondo Greanious Alfred, Mkhwananzi Blessing Nkazimulo, Mabandla Musa Vuyisile, Musabayane Cephas Tagumirwa

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in African journal of traditional, complementary, and alternative medicines : AJTCAM, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Mavondo Greanious AlfredDiscipline of Human Physiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu Natal, Westville Campus, Durban, 4000, South Africa.
Mkhwananzi Blessing NkazimuloDiscipline of Human Physiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu Natal, Westville Campus, Durban, 4000, South Africa.
Mabandla Musa VuyisileDiscipline of Human Physiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu Natal, Westville Campus, Durban, 4000, South Africa.
Musabayane Cephas TagumirwaDiscipline of Human Physiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu Natal, Westville Campus, Durban, 4000, South Africa.
University of KwaZulu-Natal · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGlucose homeostasis derangement is a common pathophysiology of malaria whose aetiology is still controversial. The MATERIALS AND

methodsAcute as well as sub-chronic studies were carried out

resultsIn acute studies, asiatic acid improved oral glucose response while in the sub-chronic state it maintained food and water intake and suppressed parasitaemia. Normoglycaemic control was maintained in infected animals through insulin suppression and increasing glucagon secretion, in both acute and chronic studies. Asiatic acid administration curtailed lactate concentration towards normal.

conclusionPer oral post-infection asiatic acid administration preserved drinking and eating habits, inhibited sickness behaviour while suppressing parasitaemia. Reciprocal relationship between insulin and glucagon concentrations was maintained influencing glucose homeostasis positively and inhibition of hyperlactaemia in malaria.

Indexed as

Plasmodium bergheiAnimalsDisease Models, AnimalGlucoseGlucose Tolerance TestHomeostasisInsulinLactic AcidMalariaMaleParasitemiaPentacyclic TriterpenesRatsRats, Sprague-Dawleyasiatic acidGlucoseInsulinLactic AcidPentacyclic Triterpenesanti-diseaseanti-parasiticAsiatic acidglucose homeostasismalariaPlasmodium berghei

Identifiers

PMID28487899
PMCPMC5416651
OpenAlexW2514057283

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.