ArticleFrontiers in immunology2017
Regulatory T Cells and Pro-inflammatory Responses Predominate in Children with Tuberculosis.
Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Pediatric Tuberculosis: Unraveling Immunity, Clinical Complexities, and Resource-Driven Disparities in the Pursuit of Prevention.Vaccines · 2026Review
- Analysis of Lymphocyte Immunologic Indexes in the Early Diagnosis of Active Pulmonary Tuberculosis of Adolescents in China.Infection and drug resistance · 2025Article
- The influence of fixation and cryopreservation of cerebrospinal fluid on antigen expression and cell percentages by flow cytometric analysis.Scientific reports · 2024Article
- Production of Proinflammatory Cytokines by CD4+ and CD8+ T Cells in Response to Mycobacterial Antigens among Children and Adults with Tuberculosis.Pathogens (Basel, Switzerland) · 2023Article
- Disseminated tuberculosis in a child during the COVID-19 pandemic: a case report and literature review.Frontiers in immunology · 2023Review
- Comparative transcriptomic analysis of whole blood mycobacterial growth assays and tuberculosis patients' blood RNA profiles.Scientific reports · 2022Article
- Article
- Malnutrition leads to increased inflammation and expression of tuberculosis risk signatures in recently exposed household contacts of pulmonary tuberculosis.Frontiers in immunology · 2022Article
- Increase of CD4+CD25highFoxP3+ cells impairs in vitro human microbicidal activity against Mycobacterium tuberculosis during latent and acute pulmonary tuberculosis.PLoS neglected tropical diseases · 2021Article
- Infection in the Developing Brain: The Role of Unique Systemic Immune Vulnerabilities.Frontiers in neurology · 2021Review
- Toll-like receptor 4 signaling-mediated responses are critically engaged in optimal host protection against highly virulentVirulence · 2020Article
- Regulatory T cells in pediatric AML are associated with disease load and their serial assessment suggests role in leukemogenesis.American journal of blood research · 2020Article
- Tuberculosis susceptibility and protection in children.The Lancet. Infectious diseases · 2019Review
- Regulatory T Cells inFrontiers in immunology · 2019Review
- Examining the Complex Relationship Between Tuberculosis and Other Infectious Diseases in Children.Frontiers in pediatrics · 2019Review
- Age-related waning of immune responses to BCG in healthy children supports the need for a booster dose of BCG in TB endemic countries.Scientific reports · 2018Article
- Risk factors for extrapulmonary dissemination of tuberculosis and associated mortality during treatment for extrapulmonary tuberculosis.Emerging microbes & infections · 2018Article
- Elevated Cyclic AMP Inhibits Mycobacterium tuberculosis-Stimulated T-cell IFN-γ Secretion Through Type I Protein Kinase A.The Journal of infectious diseases · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundFollowing infection with
objectiveTo comprehensively analyze key immune responses to mycobacteria between HIV-negative children with extrapulmonary TB (EPTB) compared to children with pulmonary TB (PTB) or healthy controls.
methodsWhole blood was stimulated
resultsSeventy-six children with TB disease (48 with PTB and 28 with EPTB) and 83 healthy controls were recruited to the study. The frequency of CD4
conclusionIn children with TB disease, a predominantly immune regulatory state is present. These immune findings do not distinguish between children with PTB and EPTB at the time of diagnosis. Following treatment, these inflammatory responses recover in PTB, suggesting that the effect is disease specific rather than due to an underlying host defect.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.