Evidence map›Paper›PMID 28487693›Full record

ReviewFrontiers in immunology2017

Advances in Autoimmune Epilepsy Associated with Antibodies, Their Potential Pathogenic Molecular Mechanisms, and Current Recommended Immunotherapies.

Zhiwei Fang, Yunqi Yang, Xuan Chen, Weiwang Zhang, Yangmei Xie, Yinghui Chen, Zhenguo Liu, Weien Yuan

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Observational
  2. Article
  3. Article
  4. Review
  5. Article
  6. Anti-Hu-related epilepsy diagnosed after surgical management.The Journal of international medical research · 2020
    Review
  7. Identifying the culprits in neurological autoimmune diseases.Journal of translational autoimmunity · 2019
    Review
  8. Review
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhiwei FangDepartment of Neurology, Xinhua Hospital Affiliated to the Medical School of Shanghai Jiao Tong University, Shanghai, China.
Yunqi YangSchool of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.
Xuan ChenSchool of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.
Weiwang ZhangSchool of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.
Yangmei XieDepartment of Neurology, Jinshan Hospital, Fudan University, Shanghai, China.
Yinghui ChenDepartment of Neurology, Jinshan Hospital, Fudan University, Shanghai, China.
Zhenguo LiuDepartment of Neurology, Xinhua Hospital Affiliated to the Medical School of Shanghai Jiao Tong University, Shanghai, China.
Weien YuanSchool of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this comprehensive article, we present an overview of some most common autoimmune antibodies believed to be potentially pathogenic for autoimmune epilepsies and elaborate their pathogenic mode of action in molecular levels based on the existing knowledge. Findings of the studies of immunemodulatory treatments for epilepsy are also discussed, and guidelines for immunotherapy are sorted out. We aim to summarize the emerging understanding of different pathogenic mechanisms of autoantibodies and clinical immunotherapy regimens to open up therapeutic possibilities for future optimum therapy. We conclude that early diagnosis of autoimmune epilepsy is of great significance, as early immune treatments have useful disease-modifying effects on some epilepsies and can facilitate the recovery.

Indexed as

autoantibodiesautoimmune epilepsyguidelinesimmunotherapypathogenic mechanism

Identifiers

PMID28487693
PMCPMC5403900

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.