ArticleFrontiers in computational neuroscience2017
Forearm Flexor Muscles in Children with Cerebral Palsy Are Weak, Thin and Stiff.
Article in Frontiers in computational neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Circulating mitochondrial-derived microproteins at rest and in response to an acute bout of endurance exercise in individuals with cerebral palsy.Experimental physiology · 2026Article
- Does Time Tick Faster in Cerebral Palsy? Accelerated Aging as a Framework for Skeletal Muscle Dysfunction.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Review
- Microscopic and molecular aspects of skeletal muscle alterations in cerebral palsy.Developmental medicine and child neurology · 2026Review
- Upper-limb range of motion in children with cerebral palsy treated with botulinum neurotoxin: a population-based cohort study.BMC musculoskeletal disorders · 2026Article
- Ultrasound Assessment of Diaphragmatic Function in Children With Cerebral Palsy: A Cross-Sectional Observational Case-Control Study.Health science reports · 2026Article
- Impact of Wrist and Finger Extension on Passive Joint Torques and Their Association with Forearm Flexor Muscle Structure in Hemiparetic Cerebral Palsy: Early Findings.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2025Article
- Quantifying structural properties of forearm flexor muscles in individuals with hemiparetic cerebral palsy using diffusion tensor imaging.Physiological reports · 2025Article
- Quantitative ultrasound of submental and masticatory muscles in children with cerebral palsy.Journal of pediatric rehabilitation medicine · 2025Article
- Extracellular vesicle characteristics and microRNA content in cerebral palsy and typically developed individuals at rest and in response to aerobic exercise.Frontiers in physiology · 2022Article
- The Contributions of Extracellular Matrix and Sarcomere Properties to Passive Muscle Stiffness in Cerebral Palsy.Frontiers in physiology · 2021Article
- A Coupled Mechanobiological Model of Muscle Regeneration In Cerebral Palsy.Frontiers in bioengineering and biotechnology · 2021Article
- Multi-frequency bioimpedance: a non-invasive tool for muscle-health assessment of adults with cerebral palsy.Journal of muscle research and cell motility · 2020Article
- Does a Reduced Number of Muscle Stem Cells Impair the Addition of Sarcomeres and Recovery from a Skeletal Muscle Contracture? A Transgenic Mouse Model.Clinical orthopaedics and related research · 2020Article
- Epigenetic Marks at the Ribosomal DNA Promoter in Skeletal Muscle Are Negatively Associated With Degree of Impairment in Cerebral Palsy.Frontiers in pediatrics · 2020Article
- Effects of spastic cerebral palsy on multi-finger coordination during isometric force production tasks.Experimental brain research · 2019Article
- Outcome of hand surgery in children with spasticity - a 9-year follow-up study.Journal of pediatric orthopedics. Part B · 2019Article
- Time Course of Upper Limb Function in Children with Unilateral Cerebral Palsy: A Five-Year Follow-Up Study.Neural plasticity · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Children with cerebral palsy (CP) often develop reduced passive range of motion with age. The determining factor underlying this process is believed to be progressive development of contracture in skeletal muscle that likely changes the biomechanics of the joints. Consequently, to identify the underlying mechanisms, we modeled the mechanical characteristics of the forearm flexors acting across the wrist joint. We investigated skeletal muscle strength (Grippit®) and passive stiffness and viscosity of the forearm flexors in 15 typically developing (TD) children (10 boys/5 girls, mean age 12 years, range 8-18 yrs) and nine children with CP Nine children (6 boys/3 girls, mean age 11 ± 3 years (yrs), range 7-15 yrs) using the NeuroFlexor® apparatus. The muscle stiffness we estimate and report is the instantaneous mechanical response of the tissue that is independent of reflex activity. Furthermore, we assessed cross-sectional area of the flexor carpi radialis (FCR) muscle using ultrasound. Age and body weight did not differ significantly between the two groups. Children with CP had a significantly weaker (-65%,
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