ArticleFrontiers in computational neuroscience2017
A Computational Analysis of the Function of Three Inhibitory Cell Types in Contextual Visual Processing.
Article in Frontiers in computational neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 45 citations in OpenAlex.
- Excitatory/inhibitory ratio disruption modulates neural synchrony and flow directions in a cortical microcircuit.PLoS computational biology · 2025Article
- State modulation in spatial networks with three interneuron subtypes.Science advances · 2025Article
- Local connections among excitatory neurons underlie characteristics of enriched environment exposure-induced neuronal response modulation in layers 2/3 of the mouse V1.Frontiers in systems neuroscience · 2025Article
- A layered microcircuit model of somatosensory cortex with three interneuron types and cell-type-specific short-term plasticity.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Simple synaptic modulations implement diverse novelty computations.Cell reports · 2024Article
- Simple synaptic modulations implement diverse novelty computations.bioRxiv : the preprint server for biology · 2024Article
- A microcircuit model involving parvalbumin, somatostatin, and vasoactive intestinal polypeptide inhibitory interneurons for the modulation of neuronal oscillation during visual processing.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
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- Preferential transduction of parvalbumin-expressing cortical neurons by AAV-mDLX5/6 vectors.Frontiers in neuroscience · 2023Article
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- Disinhibitory circuit mediated by connections from vasoactive intestinal polypeptide to somatostatin interneurons underlies the paradoxical decrease in spike synchrony with increased border ownership selective neuron firing rate.Frontiers in computational neuroscience · 2022Article
- Neural Substrates and Models of Omission Responses and Predictive Processes.Frontiers in neural circuits · 2022Review
- Self-organization of a doubly asynchronous irregular network state for spikes and bursts.PLoS computational biology · 2021Article
- NetPyNE Implementation and Scaling of the Potjans-Diesmann Cortical Microcircuit Model.Neural computation · 2021Article
- Article
- Common Principles in Functional Organization of VIP/Calretinin Cell-Driven Disinhibitory Circuits Across Cortical Areas.Frontiers in neural circuits · 2020Review
- Functional flexibility in cortical circuits.Current opinion in neurobiology · 2019Review
- Article
- A multi-scale layer-resolved spiking network model of resting-state dynamics in macaque visual cortical areas.PLoS computational biology · 2018Article
- A disinhibitory circuit motif and flexible information routing in the brain.Current opinion in neurobiology · 2018Review
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most cortical inhibitory cell types exclusively express one of three genes, parvalbumin, somatostatin and 5HT3a. We conjecture that these three inhibitory neuron types possess distinct roles in visual contextual processing based on two observations. First, they have distinctive synaptic sources and targets over different spatial extents and from different areas. Second, the visual responses of cortical neurons are affected not only by local cues, but also by visual context. We use modeling to relate structural information to function in primary visual cortex (V1) of the mouse, and investigate their role in contextual visual processing. Our findings are three-fold. First, the inhibition mediated by parvalbumin positive (PV) cells mediates local processing and could underlie their role in boundary detection. Second, the inhibition mediated by somatostatin-positive (SST) cells facilitates longer range spatial competition among receptive fields. Third, non-specific top-down modulation to interneurons expressing vasoactive intestinal polypeptide (VIP), a subclass of 5HT3a neurons, can selectively enhance V1 responses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.