ArticleScientific reports2017
Multiferroic coreshell magnetoelectric nanoparticles as NMR sensitive nanoprobes for cancer cell detection.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Magnetoelectric Nanotherapy Achieves Complete Tumor Ablation and Prolonged Survival in Pancreatic Cancer Murine Models.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Barium Titanate-Coated Cobalt Ferrite Core-Shell Magnetoelectric Nanoparticles for Wireless Actuation Technologies.ACS applied nano materials · 2025Article
- Mechanism and applications of magnetoelectric nanoparticles in cancer therapy.Nanomedicine (London, England) · 2025Review
- Exploring magnetoelectric nanoparticles for advanced nano-electroporation and drug delivery in interventional cardiology.Nanoscale advances · 2025Article
- Foundational insights for theranostic applications of magnetoelectric nanoparticles.Nanoscale horizons · 2025Review
- Catalytic Degradation of Organic Dyes Indicates Anti-Proliferative Effects of Magnetoelectric Nanoparticles.Journal of electronic materials · 2025Article
- Low-frequency magnetic fields potentiate plasma-modified magneto-electric nanoparticle drug loading for anticancer activity in vitro and in vivo.Scientific reports · 2023Article
- Biocompatible, Multi-Mode, Fluorescent,Pharmaceuticals (Basel, Switzerland) · 2022Article
- Biosensors and Drug Delivery in Oncotheranostics Using Inorganic Synthetic and Biogenic Magnetic Nanoparticles.Biosensors · 2022Review
- Recent advances, status, and opportunities of magneto-electric nanocarriers for biomedical applications.Molecular aspects of medicine · 2022Review
- Nanotechnology in cancer diagnosis: progress, challenges and opportunities.Journal of hematology & oncology · 2019Review
- Technobiology's Enabler: The Magnetoelectric Nanoparticle.Cold Spring Harbor perspectives in medicine · 2019Review
- Mapping the Brain's electric fields with Magnetoelectric nanoparticles.Bioelectronic medicine · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
11 authors.
Funding
Abstract
Magnetoelectric (ME) nanoparticles (MENs) intrinsically couple magnetic and electric fields. Using them as nuclear magnetic resonance (NMR) sensitive nanoprobes adds another dimension for NMR detection of biological cells based on the cell type and corresponding particle association with the cell. Based on ME property, for the first time we show that MENs can distinguish different cancer cells among themselves as well as from their normal counterparts. The core-shell nanoparticles are 30 nm in size and were not superparamagnetic. Due to presence of the ME effect, these nanoparticles can significantly enhance the electric field configuration on the cell membrane which serves as a signature characteristic depending on the cancer cell type and progression stage. This was clearly observed by a significant change in the NMR absorption spectra of cells incubated with MENs. In contrast, conventional cobalt ferrite magnetic nanoparticles (MNPs) did not show any change in the NMR absorption spectra. We conclude that different membrane properties of cells which result in distinct MEN organization and the minimization of electrical energy due to particle binding to the cells contribute to the NMR signal. The nanoprobe based NMR spectroscopy has the potential to enable rapid screening of cancers and impact next-generation cancer diagnostic exams.
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Registered trials
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