ArticleScientific reports2017
GIRK2 splice variants and neuronal G protein-gated K
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Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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0cells of the map it votes in
19citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
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Who cites it
19 citing papers in PubMed, 24 citations in OpenAlex.
- Molecular and cell type-specific determinants of inferior colliculus development and auditory function.bioRxiv : the preprint server for biology · 2026Article
- Live-cell quantitative monitoring reveals distinct, high-affinity Gβγ regulations of GIRK2 and GIRK1/2 channels.Nature communications · 2025Article
- Machine learning identifies lactate metabolism biomarkers and deciphers immune infiltration landscapes in Parkinson's disease.Scientific reports · 2025Article
- Live-cell quantitative monitoring reveals distinct, high-affinity Gβγ regulations of GIRK2 and GIRK1/2 channels.bioRxiv : the preprint server for biology · 2025Article
- Amyloid-β oligomers trigger sex-dependent inhibition of GIRK channel activity in hippocampal neurons in mice.Science signaling · 2024Article
- Domain-selective and sex-dependent regulation of learning and memory in mice by GIRK channel activity in CA1 pyramidal neurons of the dorsal hippocampus.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- Alcohol reverses the effects of KCNJ6 (GIRK2) noncoding variants on excitability of human glutamatergic neurons.Molecular psychiatry · 2023Article
- Spatial Memory Training Counteracts Hippocampal GIRK Channel Decrease in the Transgenic APPInternational journal of molecular sciences · 2022Article
- Neuronal G protein-gated KAmerican journal of physiology. Cell physiology · 2022Review
- Enhanced GIRK2 channel signaling in Down syndrome: A feasible role in the development of abnormal nascent neural circuits.Frontiers in genetics · 2022Review
- GIRK2 Channels in Down Syndrome and Alzheimer's Disease.Current Alzheimer research · 2022Article
- Next-generation inward rectifier potassium channel modulators: discovery and molecular pharmacology.American journal of physiology. Cell physiology · 2021Review
- Spatiotemporal Regulation of Transcript Isoform Expression in the Hippocampus.Frontiers in molecular neuroscience · 2021Article
- The antitussive cloperastine improves breathing abnormalities in a Rett Syndrome mouse model by blocking presynaptic GIRK channels and enhancing GABA release.Neuropharmacology · 2020Article
- GPCR-dependent biasing of GIRK channel signaling dynamics by RGS6 in mouse sinoatrial nodal cells.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- VU0810464, a non-urea G protein-gated inwardly rectifying KBritish journal of pharmacology · 2019Article
- Direct activation of G-protein-gated inward rectifying K+ channels promotes nonrapid eye movement sleep.Sleep · 2019Article
- Acetylcholine Release Inhibits Distinct Excitatory Inputs Onto Hippocampal CA1 Pyramidal Neurons via Different Cellular and Network Mechanisms.Frontiers in cellular neuroscience · 2019Article
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Authors and funding
11 authors at 3 institutions in 1 country.
Ezequiel Marron Fernandez de VelascoUniversity of Minnesota, Department of Pharmacology, Minneapolis, MN, 55455, USA.
Lei ZhangUniversity of Minnesota, Department of Pharmacology, Minneapolis, MN, 55455, USA.
Baovi N VoUniversity of Minnesota, Department of Pharmacology, Minneapolis, MN, 55455, USA.
Megan TippsUniversity of Minnesota, Department of Pharmacology, Minneapolis, MN, 55455, USA.
Shannon FarrisNational Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.
Zhilian XiaUniversity of Minnesota, Department of Pharmacology, Minneapolis, MN, 55455, USA.
Allison AndersonUniversity of Minnesota, Department of Pharmacology, Minneapolis, MN, 55455, USA.
Nicholas CarlblomUniversity of Minnesota, Department of Pharmacology, Minneapolis, MN, 55455, USA.
C David WeaverVanderbilt University, Department of Pharmacology, Nashville, TN, 37235, USA.
Serena M DudekNational Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.ORCID 0000-0003-4094-8368
Kevin WickmanUniversity of Minnesota, Department of Pharmacology, Minneapolis, MN, 55455, USA. wickm002@umn.edu.
University of Minnesota · USTriangle · USVanderbilt University · US
Funding
Mechanisms Of Synaptic Plasticity In The Adult And Developing Nervous SystemZIAES100221 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI DUDEK, SERENA M · 2009 to 2025
$47.4MG protein-gated K+ channels and inhibitory signalingR01MH061933 · NIMH · UNIVERSITY OF MINNESOTA TWIN CITIES · PI WICKMAN, KEVIN D · 2001 to 2016
$4.4MSynaptic Plasticity In The Adult And Developing NSZ01ES100221 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI DUDEK, SERENA M · 2002 to 2008
$3.5MRelevance and plasticity of inhibitory metabotropic signaling in reward circuitsR01DA034696 · NIDA · UNIVERSITY OF MINNESOTA · PI WICKMAN, KEVIN D · 2013 to 2022
$3.4MDevelopment of an In Vivo, Brain-penetrant GIRK1/2 Potassium Channel ActivatorR01MH107399 · NIMH · VANDERBILT UNIVERSITY · PI HOPKINS, COREY R., WEAVER, C DAVID · 2015 to 2017
$1.6MCell-Type Specific Regulation of Dendritic mRNA in the HippocampusR00MH109626 · NIMH · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI FARRIS, SHANNON · 2019 to 2021
$795kIntramural NIH HHS Z01 ES100221NIDA NIH HHS R01 DA034696NIMH NIH HHS K99 MH109626NIMH NIH HHS R00 MH109626NIMH NIH HHS R01 MH061933NIMH NIH HHS R01 MH107399
Abstract
Many neurotransmitters directly inhibit neurons by activating G protein-gated inwardly rectifying K
Indexed as
Ion Channel GatingAlternative SplicingAnimalsCalcium-Calmodulin-Dependent Protein Kinase Type 2Conditioning, PsychologicalDisks Large Homolog 4 ProteinFearG Protein-Coupled Inwardly-Rectifying Potassium ChannelsHEK293 CellsHippocampusHumansIntegrasesLearningMice, Inbred C57BLNeuronsProtein IsoformsCalcium-Calmodulin-Dependent Protein Kinase Type 2Cre recombinaseDisks Large Homolog 4 ProteinDlg4 protein, mouseG Protein-Coupled Inwardly-Rectifying Potassium ChannelsIntegrasesProtein Isoforms
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.