Evidence map›Paper›PMID 28487438›Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2017

The Niemann-Pick C1 gene interacts with a high-fat diet to promote weight gain through differential regulation of central energy metabolism pathways.

Joseph J Castillo, David Jelinek, Hao Wei, Nicholas P Gannon, Roger A Vaughan, L John Horwood, F John Meaney, Randi Garcia-Smith, Kristina A Trujillo, Randall A Heidenreich and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
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  4. Review
  5. The Combined Partial Knockdown ofAntioxidants (Basel, Switzerland) · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 3 countries.

Joseph J CastilloDepartment of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico.
David JelinekDepartment of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico.
Hao WeiDepartment of Medicine, University of Washington Health Sciences Center, Seattle, Washington.
Nicholas P GannonDepartment of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico.
Roger A VaughanDepartment of Exercise Science, High Point University, High Point, North Carolina.
L John HorwoodDepartment of Psychological Medicine, University of Otago, Christchurch, New Zealand.
F John MeaneyDepartment of Pediatrics, University of Arizona Health Sciences Center, Tucson, Arizona.
Randi Garcia-SmithDepartment of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico.
Kristina A TrujilloDepartment of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico.
Randall A HeidenreichDepartment of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque, New Mexico; and.
David MeyreDepartment of Clinical Epidemiology and Biostatistics, and Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario.
Robert A OrlandoDepartment of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico.
Renee C LeBoeufDepartment of Medicine, University of Washington Health Sciences Center, Seattle, Washington.
William S GarverDepartment of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico; wgarver@unm.edu.
University of New Mexico · USUniversity of Washington · USHigh Point University · USMcMaster University · CAUniversity of Arizona · USUniversity of Otago · NZ

Funding

LIPID, LIPOPROTEIN, AND GLUCOSE METABOLISM COREU24DK059630 · NIDDK · UNIVERSITY OF CINCINNATI · PI TSO, PATRICK · 2001 to 2015
$12.9M
MMPC: Diabetes and Diabectic ComplicationsU24DK076126 · NIDDK · UNIVERSITY OF WASHINGTON · PI LEBOEUF, RENEE C · 2006 to 2010
$4.8M
Insulin Resistance and ABCA1 Transporter FunctionR21DK071544 · NIDDK · UNIVERSITY OF ARIZONA · PI GARVER, WILLIAM S · 2005 to 2006
$372k
NIDDK NIH HHS R21 DK071544NIDDK NIH HHS U24 DK059630NIDDK NIH HHS U24 DK076126
6 · The paper itself

Abstract

A genome-wide association study (GWAS) reported that common variation in the human Niemann-Pick C1 gene (

Indexed as

Gene-Environment InteractionAnimalsCells, CulturedDiet, High-FatEnergy MetabolismGene Expression RegulationIntracellular Signaling Peptides and ProteinsLiverMaleMetabolic Networks and PathwaysMiceMice, Inbred BALB CMice, TransgenicNiemann-Pick C1 ProteinProteinsWeight GainIntracellular Signaling Peptides and ProteinsNiemann-Pick C1 ProteinNpc1 protein, mouseProteinsadiposefibroblastliverNiemann-Pick C1obesity

Identifiers

PMID28487438
PMCPMC5582887
OpenAlexW2612832393

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.