Evidence map›Paper›PMID 28487382›Full record

ArticleRNA (New York, N.Y.)2017

NF45 and NF90/NF110 coordinately regulate ESC pluripotency and differentiation.

Julia Ye, Hu Jin, Aleksandr Pankov, Jun S Song, Robert Blelloch

Abstract read
In one paragraph

Article in RNA (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. The Polyvalent Role of NF90 in RNA Biology.International journal of molecular sciences · 2022
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Julia YeThe Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Center for Reproductive Sciences, University of California, San Francisco, San Francisco, California 94143, USA.
Hu JinCarl R. Woese Institute for Genomic Biology, University of Illinois, Urbana-Champaign, Urbana, Illinois 61801, USA.
Aleksandr PankovDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California 94158, USA.
Jun S SongCarl R. Woese Institute for Genomic Biology, University of Illinois, Urbana-Champaign, Urbana, Illinois 61801, USA.
Robert BlellochThe Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Center for Reproductive Sciences, University of California, San Francisco, San Francisco, California 94143, USA.

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007618 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDERSON, MARK S · 1985 to 2020
$29.6M
Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VAISSE, CHRISTIAN · 2003 to 2019
$21.8M
Predicting Transcriptional and Epigenetic Networks in Cancer from Sequencing DataR01CA163336 · NCI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Jun S Song · 2012 to 2026
$4.4M
MicroRNA Based Pathway Discovery in Cellular ReprogrammingR01GM101180 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BLELLOCH, ROBERT · 2012 to 2015
$1.4M
Role of interleukin enhancer-binding factor 2 (Ilf2) in mouse embryonic stem cellsF30HD084120 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI YE, JULIA · 2015 to 2017
$106k
NCI NIH HHS R01 CA163336NICHD NIH HHS F30 HD084120NIDDK NIH HHS P30 DK063720NIGMS NIH HHS R01 GM101180NIGMS NIH HHS T32 GM007618
6 · The paper itself

Abstract

While years of investigation have elucidated many aspects of embryonic stem cell (ESC) regulation, the contributions of post-transcriptional and translational mechanisms to the pluripotency network remain largely unexplored. In particular, little is known in ESCs about the function of RNA binding proteins (RBPs), the protein agents of post-transcriptional regulation. We performed an unbiased RNAi screen of RBPs in an ESC differentiation assay and identified two related genes,

Indexed as

AnimalsCell DifferentiationCell ProliferationCells, CulturedEmbryonic Stem CellsGene Expression RegulationGene Knockdown TechniquesMiceNuclear Factor 45 ProteinNuclear Factor 90 ProteinsProtein BindingRNA InterferenceIlf2 protein, mouseIlf3 protein, mouseNuclear Factor 45 ProteinNuclear Factor 90 ProteinsNF45NF90/NF110pluripotencypost-transcriptional regulationRNA-binding protein

Identifiers

PMID28487382
PMCPMC5513071

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.