Evidence map›Paper›PMID 28487368›Full record

ArticleThe Journal of biological chemistry2017

Matrix Gla protein deficiency impairs nasal septum growth, causing midface hypoplasia.

Juliana Marulanda, Hazem Eimar, Marc D McKee, Michelle Berkvens, Valentin Nelea, Hassem Roman, Teresa Borrás, Faleh Tamimi, Mathieu Ferron, Monzur Murshed

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 37 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. TheCurrent issues in molecular biology · 2024
    Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Neural crest-specific deletion ofDisease models & mechanisms · 2021
    Article
  12. Keutel Syndrome, a Review of 50 Years of Literature.Frontiers in cell and developmental biology · 2021
    Review
  13. Divergent Expression ofFrontiers in genetics · 2021
    Article
  14. BONE MARKERS IN ARTHROPATHIES.Acta clinica Croatica · 2019
    Review
  15. Article
  16. Mechanism of Bone Mineralization.Cold Spring Harbor perspectives in medicine · 2018
    Review
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Juliana MarulandaFrom the Faculty of Dentistry, McGill University, Montreal, Quebec H3A 1G1, Canada.
Hazem EimarFrom the Faculty of Dentistry, McGill University, Montreal, Quebec H3A 1G1, Canada.
Marc D McKeeFrom the Faculty of Dentistry, McGill University, Montreal, Quebec H3A 1G1, Canada.
Michelle BerkvensFrom the Faculty of Dentistry, McGill University, Montreal, Quebec H3A 1G1, Canada.
Valentin NeleaFrom the Faculty of Dentistry, McGill University, Montreal, Quebec H3A 1G1, Canada.
Hassem Romanthe Department of Anatomy and Cell Biology, Faculty of Medicine, McGill University, Montreal, Quebec H3A 0C7, Canada.
Teresa Borrásthe Department of Ophthalmology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27516.
Faleh TamimiFrom the Faculty of Dentistry, McGill University, Montreal, Quebec H3A 1G1, Canada.
Mathieu Ferronthe Institut de Recherches Cliniques de Montréal, Montréal, Quebec H2W 1R7, Canada, and.
Monzur MurshedFrom the Faculty of Dentistry, McGill University, Montreal, Quebec H3A 1G1, Canada, monzur.murshed@mcgill.ca.
McGill University · CAMontreal Clinical Research Institute · CAUniversity of North Carolina at Chapel Hill · US

Funding

PRESSURE REGULATION OF HUMAN TRABECULAR MESHWORK GENESR01EY013126 · NEI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BORRAS, TERESA · 2000 to 2012
$4.1M
Targeting calcification/ stiffness in glaucoma with Matrix GlaR01EY026220 · NEI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MEI, HUA · 2016 to 2020
$1.9M
CIHR 123310NEI NIH HHS R01 EY013126NEI NIH HHS R01 EY026220
6 · The paper itself

Abstract

Genetic and environmental factors may lead to abnormal growth of the orofacial skeleton, affecting the overall structure of the face. In this study, we investigated the craniofacial abnormalities in a mouse model for Keutel syndrome, a rare genetic disease caused by loss-of-function mutations in the matrix Gla protein (

Indexed as

CalcinosisChondrocytesCraniofacial AbnormalitiesNasal SeptumAnimalsCalcium-Binding ProteinsExtracellular Matrix ProteinsHumansMatrix Gla ProteinMiceMice, KnockoutCalcium-Binding ProteinsExtracellular Matrix ProteinsMatrix Gla Proteinapoptosisbiomineralizationchondrocytecraniofacial developmentmatrix Gla protein (MGP)midface hypoplasiamouse geneticsnasal septum

Identifiers

PMID28487368
PMCPMC5500805
OpenAlexW2613448732

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.