Evidence map›Paper›PMID 28487362›Full record

ArticleThe Journal of biological chemistry2017

Complex binding pathways determine the regeneration of mammalian green cone opsin with a locked retinal analogue.

Nathan S Alexander, Kota Katayama, Wenyu Sun, David Salom, Sahil Gulati, Jianye Zhang, Muneto Mogi, Krzysztof Palczewski, Beata Jastrzebska

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Advances and therapeutic opportunities in visual cycle modulation.Progress in retinal and eye research · 2025
    Review
  3. Article
  4. Review
  5. Human red and green cone opsins areThe Journal of biological chemistry · 2019
    Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Nathan S AlexanderFrom the Department of Pharmacology, School of Medicine and.
Kota KatayamaFrom the Department of Pharmacology, School of Medicine and.
Wenyu SunPolgenix Inc., Cleveland, Ohio 44106, and.
David SalomFrom the Department of Pharmacology, School of Medicine and.
Sahil GulatiFrom the Department of Pharmacology, School of Medicine and.
Jianye ZhangFrom the Department of Pharmacology, School of Medicine and.
Muneto Mogithe Novartis Institutes for BioMedical Research, Inc., Cambridge, Massachusetts 02139.
Krzysztof PalczewskiFrom the Department of Pharmacology, School of Medicine and kxp65@case.edu.
Beata JastrzebskaFrom the Department of Pharmacology, School of Medicine and bxj27@case.edu.
Case Western Reserve University · USNovartis (United States) · USPolgenix (United States) · US

Funding

STRUCTURAL STUDIES OF ARRESTINSR01EY009339 · NEI · UNIVERSITY OF WASHINGTON · PI KISER, PHILIP DAVID, PALCZEWSKI, KRZYSZTOF · 1992 to 2025
$16.0M
Novel therapies to inhibit Diabetic RetinopathyR24EY024864 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI KERN, TIMOTHY S · 2015 to 2019
$8.1M
Use of systems pharmacology to prevent rod and cone photoreceptor degenerationR24EY027283 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI PALCZEWSKI, KRZYSZTOF · 2017 to 2021
$7.9M
Non-hydrolysable analogs of retinal chromophore; potential new therapeutics to prevent retinal degenerationR01EY025214 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI JASTRZEBSKA, BEATA · 2016 to 2020
$1.8M
Structural investigations of native and mutant human green cone pigmentK99EY025007 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI ALEXANDER, NATHAN · 2015 to 2016
$188k
NEI NIH HHS K99 EY025007NEI NIH HHS R01 EY009339NEI NIH HHS R01 EY025214NEI NIH HHS R24 EY024864NEI NIH HHS R24 EY027283
6 · The paper itself

Abstract

Phototransduction is initiated when the absorption of light converts the 11-

Indexed as

Models, MolecularAnimalsHumansOpsinsRetinaldehydeSf9 CellsSpodopteraOpsinsRetinaldehydeG protein-coupled receptor (GPCR)membrane proteinphotoreceptorretinoidrhodopsin

Identifiers

PMID28487362
PMCPMC5491782
OpenAlexW2612536174

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.