Evidence map›Paper›PMID 28487326›Full record

ArticleStroke2017

XBP1 (X-Box-Binding Protein-1)-Dependent O-GlcNAcylation Is Neuroprotective in Ischemic Stroke in Young Mice and Its Impairment in Aged Mice Is Rescued by Thiamet-G.

Meng Jiang, Shu Yu, Zhui Yu, Huaxin Sheng, Ying Li, Shuai Liu, David S Warner, Wulf Paschen, Wei Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.

  1. Pooled it
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  15. O-GlcNAcylation in ischemic diseases.Frontiers in pharmacology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Meng JiangFrom the Multidisciplinary Neuroprotection Laboratories, Department of Anesthesiology, Duke University Medical Center, Durham, NC (M.J., S.Y., Z.Y., H.S., Y.L., S.L., D.S.W., W.P., W.Y.); Department of Anesthesiology (M.J.) and Department of Critical Care Medicine (Z.Y.), Renmin Hospital of Wuhan University, China; Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Collaborative Innovation Center of Neuroregeneration, Nantong University, China (S.Y.); and Department of Cardiology, The Fifth Central Hospital of Tianjin, China (Y.L.).
Shu YuFrom the Multidisciplinary Neuroprotection Laboratories, Department of Anesthesiology, Duke University Medical Center, Durham, NC (M.J., S.Y., Z.Y., H.S., Y.L., S.L., D.S.W., W.P., W.Y.); Department of Anesthesiology (M.J.) and Department of Critical Care Medicine (Z.Y.), Renmin Hospital of Wuhan University, China; Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Collaborative Innovation Center of Neuroregeneration, Nantong University, China (S.Y.); and Department of Cardiology, The Fifth Central Hospital of Tianjin, China (Y.L.).
Zhui YuFrom the Multidisciplinary Neuroprotection Laboratories, Department of Anesthesiology, Duke University Medical Center, Durham, NC (M.J., S.Y., Z.Y., H.S., Y.L., S.L., D.S.W., W.P., W.Y.); Department of Anesthesiology (M.J.) and Department of Critical Care Medicine (Z.Y.), Renmin Hospital of Wuhan University, China; Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Collaborative Innovation Center of Neuroregeneration, Nantong University, China (S.Y.); and Department of Cardiology, The Fifth Central Hospital of Tianjin, China (Y.L.).
Huaxin ShengFrom the Multidisciplinary Neuroprotection Laboratories, Department of Anesthesiology, Duke University Medical Center, Durham, NC (M.J., S.Y., Z.Y., H.S., Y.L., S.L., D.S.W., W.P., W.Y.); Department of Anesthesiology (M.J.) and Department of Critical Care Medicine (Z.Y.), Renmin Hospital of Wuhan University, China; Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Collaborative Innovation Center of Neuroregeneration, Nantong University, China (S.Y.); and Department of Cardiology, The Fifth Central Hospital of Tianjin, China (Y.L.).
Ying LiFrom the Multidisciplinary Neuroprotection Laboratories, Department of Anesthesiology, Duke University Medical Center, Durham, NC (M.J., S.Y., Z.Y., H.S., Y.L., S.L., D.S.W., W.P., W.Y.); Department of Anesthesiology (M.J.) and Department of Critical Care Medicine (Z.Y.), Renmin Hospital of Wuhan University, China; Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Collaborative Innovation Center of Neuroregeneration, Nantong University, China (S.Y.); and Department of Cardiology, The Fifth Central Hospital of Tianjin, China (Y.L.).
Shuai LiuFrom the Multidisciplinary Neuroprotection Laboratories, Department of Anesthesiology, Duke University Medical Center, Durham, NC (M.J., S.Y., Z.Y., H.S., Y.L., S.L., D.S.W., W.P., W.Y.); Department of Anesthesiology (M.J.) and Department of Critical Care Medicine (Z.Y.), Renmin Hospital of Wuhan University, China; Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Collaborative Innovation Center of Neuroregeneration, Nantong University, China (S.Y.); and Department of Cardiology, The Fifth Central Hospital of Tianjin, China (Y.L.).
David S WarnerFrom the Multidisciplinary Neuroprotection Laboratories, Department of Anesthesiology, Duke University Medical Center, Durham, NC (M.J., S.Y., Z.Y., H.S., Y.L., S.L., D.S.W., W.P., W.Y.); Department of Anesthesiology (M.J.) and Department of Critical Care Medicine (Z.Y.), Renmin Hospital of Wuhan University, China; Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Collaborative Innovation Center of Neuroregeneration, Nantong University, China (S.Y.); and Department of Cardiology, The Fifth Central Hospital of Tianjin, China (Y.L.).
Wulf PaschenFrom the Multidisciplinary Neuroprotection Laboratories, Department of Anesthesiology, Duke University Medical Center, Durham, NC (M.J., S.Y., Z.Y., H.S., Y.L., S.L., D.S.W., W.P., W.Y.); Department of Anesthesiology (M.J.) and Department of Critical Care Medicine (Z.Y.), Renmin Hospital of Wuhan University, China; Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Collaborative Innovation Center of Neuroregeneration, Nantong University, China (S.Y.); and Department of Cardiology, The Fifth Central Hospital of Tianjin, China (Y.L.). wulf.paschen@duke.edu wei.yang@duke.edu.
Wei YangFrom the Multidisciplinary Neuroprotection Laboratories, Department of Anesthesiology, Duke University Medical Center, Durham, NC (M.J., S.Y., Z.Y., H.S., Y.L., S.L., D.S.W., W.P., W.Y.); Department of Anesthesiology (M.J.) and Department of Critical Care Medicine (Z.Y.), Renmin Hospital of Wuhan University, China; Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Collaborative Innovation Center of Neuroregeneration, Nantong University, China (S.Y.); and Department of Cardiology, The Fifth Central Hospital of Tianjin, China (Y.L.). wulf.paschen@duke.edu wei.yang@duke.edu.
Nantong University · CNWuhan University · CNRenmin Hospital of Wuhan University · CN

Funding

The Unfolded Protein Response in Ischemic StrokeR01NS099590 · NINDS · DUKE UNIVERSITY · PI Wei Yang · 2016 to 2026
$3.7M
Role of SUMO Conjugation in Ischemia: Significance, Mechanisms and PathwaysR01NS081299 · NINDS · DUKE UNIVERSITY · PI PASCHEN, WULF · 2012 to 2016
$1.7M
Effect of Aging on Brain Ischemia/Stroke Outcome; Pathways, Mechanisms, and RescueR01NS097554 · NINDS · DUKE UNIVERSITY · PI YANG, WEI · 2016 to 2018
$1.0M
NINDS NIH HHS R01 NS081299NINDS NIH HHS R01 NS097554NINDS NIH HHS R01 NS099590
6 · The paper itself

Abstract

background and purposeImpaired protein homeostasis induced by endoplasmic reticulum dysfunction is a key feature of a variety of age-related brain diseases including stroke. To restore endoplasmic reticulum function impaired by stress, the unfolded protein response is activated. A key unfolded protein response prosurvival pathway is controlled by the endoplasmic reticulum stress sensor (inositol-requiring enzyme-1), XBP1 (downstream X-box-binding protein-1), and O-GlcNAc (O-linked β-N-acetylglucosamine) modification of proteins (O-GlcNAcylation). Stroke impairs endoplasmic reticulum function, which activates unfolded protein response. The rationale of this study was to explore the potentials of the IRE1/XBP1/O-GlcNAc axis as a target for neuroprotection in ischemic stroke.

methodsMice with

resultsDeletion of

conclusionsOur study indicates a critical role for the IRE1/XBP1 unfolded protein response branch in stroke outcome. O-GlcNAcylation is a prosurvival pathway that is activated in the stroke penumbra in young mice but impaired in aged mice. Boosting prosurvival pathways to counterbalance the age-related decline in the brain's self-healing capacity could be a promising strategy to improve ischemic stroke outcome in aged brains.

Indexed as

AcetylglucosamineAge FactorsAnimalsBrain IschemiaDisease Models, AnimalInfarction, Middle Cerebral ArteryMaleMembrane ProteinsMiceMice, Inbred C57BLMice, TransgenicNeuroprotectionProtein FoldingProtein Serine-Threonine KinasesPyransStrokeAcetylglucosamineErn2 protein, mouseMembrane ProteinsProtein Serine-Threonine KinasesPyransthiamet GThiazolesX-Box Binding Protein 1Xbp1 protein, mouseischemic strokeneuroprotectionO-GlcNActhiamet-GXBP1

Identifiers

PMID28487326
PMCPMC5493893
OpenAlexW2612741402

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.