ArticleThe Journal of experimental medicine2017
Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome.
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Article in The Journal of experimental medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 230 papers, 1 of them a synthesis that pooled it.
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230citing papers in PubMed, 1 pooled it
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Who cites it
230 citing papers in PubMed, 1 synthesis or guideline pooled it, 357 citations in OpenAlex.
- Differentially Expressed miRNAs in Ulcerative Colitis and Crohn's Disease.Frontiers in immunology · 2022Pooled it
- A randomized, double-blind phase 1b study evaluating the safety, tolerability, pharmacokinetics and pharmacodynamics of the NLRP3 inhibitor selnoflast in patients with moderate to severe active ulcerative colitis.Clinical and translational medicine · 2023Trial
- "Radiation-Synthesized Gallotannin Hydrogel Attenuates Trisenox-Induced Nephrotoxicity in Rats: miR-223/TXNIP Axis Modulation of Oxidative Stress and Inflammation".Biological trace element research · 2026Article
- MicroRNA-223 Enhances Microglia-Dependent Clearance of Amyloid Beta Plaques and Ameliorates Behavioral Deficits in a Mouse Model of Alzheimer's Disease.bioRxiv : the preprint server for biology · 2026Article
- Indirect inhibition of the NLRP3-interleukin-1β axis contributes to the efficacy of JAK1 inhibitors in experimental colitis and human ulcerative colitis.Nature communications · 2026Article
- Epigenetic Alterations in Microbiome-Host Interactions in Inflammatory and Autoimmune Diseases.International journal of molecular sciences · 2026Review
- Interplay Among Endothelial Dysfunction, NLRP3 Pathway Activation, and microRNAs in the Pathogenesis of Preeclampsia.Diseases (Basel, Switzerland) · 2026Review
- Investigation of miRNAs Associated with Inflammation and Apoptosis in Patients with Idiopathic Trigeminal Neuralgia.Diagnostics (Basel, Switzerland) · 2026Article
- MicroRNA‑microbiome cross‑kingdom networks drive inflammatory bowel disease through dynamic regulatory ecosystems (Review).International journal of molecular medicine · 2026Review
- Gut Microbiota-Non-Coding RNA Axis in Immune Modulation and Disease: From Mechanisms to Clinical Translation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- MicroRNAs in Long COVID: Key Regulators, Biomarkers, and Therapeutic Targets of Post-SARS-CoV-2 Sequelae.Biomolecules · 2026Review
- UHRF1 deficiency exacerbates intestinal inflammation by epigenetic modulation of NPY1R gene methylation.JCI insight · 2026Article
- MicroRNA-223/NE Signaling Pathway Inhibits Lipopolysaccharide-Induced Acute Lung Injury by Regulating Neutrophil Extracellular Traps.Mediators of inflammation · 2026Article
- Irisin hampers β-amyloid-induced microglial inflammationFrontiers in immunology · 2026Article
- Gut microbiota dysbiosis and immune responses: insights from IgA nephropathy and inflammatory bowel disease.Frontiers in immunology · 2026Review
- Interplay Between Dysregulated Immune System and the Footprints of Blood-Borne miRNAs in Treatment Naive Crohn's Disease and Ulcerative Colitis Patients.International journal of molecular sciences · 2025Article
- SGLT2 Inhibitors Confer Cardiovascular Protection via the Gut-Kidney-Heart Axis: Mechanisms and Translational Perspectives.Journal of cardiovascular development and disease · 2025Review
- Review
- Global research trends in non-coding RNA and intestinal epithelial homeostasis: an integrated bibliometric analysis (2007-2024).Hereditas · 2025Article
- Therapeutic Potential of Modulating Gene-MicroRNA Crosstalk in Burn Injury.International journal of molecular sciences · 2025Review
170 more citing papers are in PubMed but not listed here.
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Authors and funding
19 authors at 7 institutions in 5 countries.
Viola NeudeckerClinic for Anesthesiology, University Hospital of Ludwig-Maximilians-University, 80539 Munich, Germany.ORCID 0000-0003-3021-5523
Moritz HaneklausSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.ORCID 0000-0003-1529-9677
Owen JensenMucosal Inflammation Program, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045.ORCID 0000-0002-6670-4743
Ludmila KhailovaDepartment of Anesthesiology, School of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045.
Joanne C MastersonGastrointestinal Eosinophilic Disease Program, Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Children's Hospital Colorado, Aurora, CO 80045.ORCID 0000-0002-8336-9879
Hazel TyeDivision of Inflammation, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
Kathryn BietteGastrointestinal Eosinophilic Disease Program, Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Children's Hospital Colorado, Aurora, CO 80045.ORCID 0000-0002-6378-7053
Paul JedlickaDepartment of Pathology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045.
Kelley S BrodskyDepartment of Anesthesiology, School of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045.ORCID 0000-0003-0732-7703
Mark E GerichDivision of Gastroenterology and Hepatology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045.
Matthias MackDepartment of Internal Medicine II, University Hospital Regensburg, 93053 Regensburg, Germany.
Avril A B RobertsonInstitute for Molecular Bioscience, The University of Queensland, Brisbane City, QLD 4067, Australia.
Matthew A CooperInstitute for Molecular Bioscience, The University of Queensland, Brisbane City, QLD 4067, Australia.ORCID 0000-0003-3147-3460
Glenn T FurutaGastrointestinal Eosinophilic Disease Program, Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Children's Hospital Colorado, Aurora, CO 80045.ORCID 0000-0003-3262-3571
Charles A DinarelloDepartment of Medicine, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.
Luke A O'NeillSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
Holger K EltzschigDepartment of Anesthesiology, University of Texas Medical School at Houston, Houston, TX 77030.
Seth L MastersDivision of Inflammation, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.ORCID 0000-0003-4763-576X
Eóin N McNameeMucosal Inflammation Program, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045 eoin.mcnamee@ucdenver.edu.ORCID 0000-0002-3331-3148
University of Colorado Anschutz Medical Campus · USChildren's Hospital Colorado · USThe University of Melbourne · AUThe University of Queensland · AUTrinity College Dublin · IERadboud University Nijmegen · NLUniversity Hospital Regensburg · DE
Funding
Trangenic Mouse Breeding CoreP01HL114457 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI XIA, YANG · 2013 to 2017
$10.0MNovel Immunologic Effects of Semaphorin 7a in IPFR01HL109233 · NHLBI · YALE UNIVERSITY · PI HERZOG, ERICA L · 2011 to 2019
$3.7MHypoxia-Inducible Factors in Acetaminophen-Induced Liver Injury.R01DK109574 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ELTZSCHIG, HOLGER K., JU, CYNTHIA · 2016 to 2019
$1.8MProton Pump Inhibitors for Perioperative Acute Kidney InjuryR01DK097075 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ELTZSCHIG, HOLGER K. · 2013 to 2017
$1.7MHypoxia Inducible Factor in Acute Lung InjuryR01HL098294 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI ELTZSCHIG, HOLGER K. · 2011 to 2014
$1.6MAmphiregulin Signaling in Perioperative Cardio-ProtectionR01HL119837 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ELTZSCHIG, HOLGER K. · 2014 to 2017
$1.5MMicroRNA Shuttling during Acute Respiratory Distress SyndromeR01HL133900 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ELTZSCHIG, HOLGER K. · 2017 to 2020
$1.5MReduction of kidney progressive fibrosis by A2A adenosine receptor activation: PR01DK082509 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI GARCIA, GABRIELA E · 2011 to 2015
$1.3MHypoxia Inducible Factor Control of Epithelial Regeneration in Eosinophilic EsophagitisK01DK106315 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI MASTERSON, JOANNE CAROL · 2015 to 2017
$415kNHLBI NIH HHS P01 HL114457NHLBI NIH HHS R01 HL098294NHLBI NIH HHS R01 HL109233NHLBI NIH HHS R01 HL119837NHLBI NIH HHS R01 HL133900NIDDK NIH HHS K01 DK106315NIDDK NIH HHS R01 DK082509NIDDK NIH HHS R01 DK097075NIDDK NIH HHS R01 DK109574
Abstract
MicroRNA (miRNA)-mediated RNA interference regulates many immune processes, but how miRNA circuits orchestrate aberrant intestinal inflammation during inflammatory bowel disease (IBD) is poorly defined. Here, we report that miR-223 limits intestinal inflammation by constraining the nlrp3 inflammasome. miR-223 was increased in intestinal biopsies from patients with active IBD and in preclinical models of intestinal inflammation.
Indexed as
AdultAnimalsAntibodiesBase SequenceColitisDextran SulfateDisease SusceptibilityHematopoiesisHumansInflammasomesInflammationInflammatory Bowel DiseasesInterleukin-1betaIntestinesMice, Inbred C57BLMice, KnockoutAntibodiesCcr2 protein, mouseDextran SulfateInflammasomesInterleukin-1betaMicroRNAsMIR223, humanMIRN223 microRNA, mouseNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humanNlrp3 protein, mouseReceptors, CCR2
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LicenceCC BY-NC-SA
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.