Evidence map›Paper›PMID 28487131›Full record

ReviewSeminars in immunology2017

Dendritic cells in the host response to implanted materials.

Benjamin G Keselowsky, Jamal S Lewis

Abstract readReview
In one paragraph

Review in Seminars in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Prevention of the foreign body response to implantable medical devices by inflammasome inhibition.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  10. Review
  11. Article
  12. Article
  13. Dendritic cell biocompatibility of ether-based urethane films.Journal of applied toxicology : JAT · 2021
    Article
  14. Review
  15. Article
  16. An injectable PEG hydrogel controlling neurotrophin-3 release by affinity peptides.Journal of controlled release : official journal of the Controlled Release Society · 2021
    Article
  17. Article
  18. Review
  19. Review
  20. Biomaterials: Foreign Bodies or Tuners for the Immune Response?International journal of molecular sciences · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Benjamin G KeselowskyJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611 USA. Electronic address: bkeselowsky@bme.ufl.edu.
Jamal S LewisDepartment of Biomedical Engineering, University of California, Davis, CA 95616, USA.

Funding

Dendritic Cell-Targeting Microparticles for Subcellularly-Targeted Delivery of InR01DK091658 · NIDDK · UNIVERSITY OF FLORIDA · PI KESELOWSKY, BENJAMIN GEORGE · 2012 to 2016
$1.6M
Biomaterial Delivery System for Type 1 Diabetes VaccineR01DK098589 · NIDDK · UNIVERSITY OF FLORIDA · PI KESELOWSKY, BENJAMIN GEORGE · 2014 to 2017
$1.5M
NIDDK NIH HHS R01 DK091658NIDDK NIH HHS R01 DK098589
6 · The paper itself

Abstract

The role of dendritic cells (DCs) and their targeted manipulation in the body's response to implanted materials is an important and developing area of investigation, and a large component of the emerging field of biomaterials-based immune engineering. The key position of DCs in the immune system, serving to bridge innate and adaptive immunity, is facilitated by rich diversity in type and function and places DCs as a critical mediator to biomaterials of both synthetic and natural origins. This review presents current views regarding DC biology and summarizes recent findings in DC responses to implanted biomaterials. Based on these findings, there is promise that the directed programming of application-specific DC responses to biomaterials can become a reality, enabling and enhancing applications almost as diverse as the larger field of biomaterials itself.

Indexed as

Prostheses and ImplantsAdaptive ImmunityAnimalsBiocompatible MaterialsDendritic CellsForeign-Body ReactionHumansImmunity, InnateRegenerative MedicineTissue EngineeringBiocompatible MaterialsBiomaterialsDendritic cellsForeign body responseImmunologyMicroparticlesScaffolds

Identifiers

PMID28487131
PMCPMC5612375

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.