ArticleBMC medicine2017
Habitual coffee consumption and genetic predisposition to obesity: gene-diet interaction analyses in three US prospective studies.
Article in BMC medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00005152 (Nurses' Health Study), which is not on this map. Cited by 30 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Nurses' Health Study (Cardiovascular Component)
Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Interactions between Polygenic Risk of Obesity and Dietary Factors on Anthropometric Outcomes: A Systematic Review and Meta-Analysis of Observational Studies.The Journal of nutrition · 2024Pooled it
- In the context of the triple burden of malnutrition: A systematic review of gene-diet interactions and nutritional status.Critical reviews in food science and nutrition · 2024Pooled it
- Habitual coffee intake and risk for nonalcoholic fatty liver disease: a two-sample Mendelian randomization study.European journal of nutrition · 2021Pooled it
- CYP1A2 polymorphisms modify the association of habitual coffee consumption with appetite, macronutrient intake, and body mass index: results from an observational cohort and a cross-over randomized study.International journal of obesity (2005) · 2022Trial
- Causal relationship between diet and common female diseases: a comprehensive Mendelian randomization study.BMC women's health · 2025Article
- [Innovative Practices of Precision Nutrition in Obesity Intervention: From Theory to Application].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025Article
- Article
- Genome-wide association studies of coffee intake in UK/US participants of European ancestry uncover cohort-specific genetic associations.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Association of genetic risk, lifestyle, and their interaction with obesity and obesity-related morbidities.Cell metabolism · 2024Article
- Metabolic shifts during coffee consumption refresh the immune response: insight from comprehensive multiomics analysis.MedComm · 2024Article
- A genomics perspective of personalized prevention and management of obesity.Human genomics · 2024Review
- Interactions Between Genetic Risk Score and Healthy Plant Diet Index on Cardiometabolic Risk Factors Among Obese and Overweight Women.Clinical nutrition research · 2023Article
- Effects of gene-lifestyle interactions on obesity based on a multi-locus risk score: A cross-sectional analysis.PloS one · 2023Article
- Healthy beverages may reduce the genetic risk of abdominal obesity and related metabolic comorbidities: a gene-diet interaction study in Iranian women.Diabetology & metabolic syndrome · 2022Article
- Fruit intake, genetic risk and type 2 diabetes: a population-based gene-diet interaction analysis.European journal of nutrition · 2021Article
- Healthful plant-based dietary patterns, genetic risk of obesity, and cardiovascular risk in the UK biobank study.Clinical nutrition (Edinburgh, Scotland) · 2021Article
- Polygenic risk for obesity and its interaction with lifestyle and sociodemographic factors in European children and adolescents.International journal of obesity (2005) · 2021Article
- Correlations between Coffee Consumption and Metabolic Phenotypes, Plasma Folate, and Vitamin B12: NHANES 2003 to 2006.Nutrients · 2021Article
- Observational
- The "Virtual Digital Twins" Concept in Precision Nutrition.Advances in nutrition (Bethesda, Md.) · 2020Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
backgroundWhether habitual coffee consumption interacts with the genetic predisposition to obesity in relation to body mass index (BMI) and obesity is unknown.
methodsWe analyzed the interactions between genetic predisposition and habitual coffee consumption in relation to BMI and obesity risk in 5116 men from the Health Professionals Follow-up Study (HPFS), in 9841 women from the Nurses' Health Study (NHS), and in 5648 women from the Women's Health Initiative (WHI). The genetic risk score was calculated based on 77 BMI-associated loci. Coffee consumption was examined prospectively in relation to BMI.
resultsThe genetic association with BMI was attenuated among participants with higher consumption of coffee than among those with lower consumption in the HPFS (P
conclusionsHigher coffee consumption might attenuate the genetic associations with BMI and obesity risk, and individuals with greater genetic predisposition to obesity appeared to have lower BMI associated with higher coffee consumption.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.