Evidence map›Paper›PMID 28486838›Full record

ArticleAIDS research and human retroviruses2017

Brain Microglial Cells Are Highly Susceptible to HIV-1 Infection and Spread.

Jennifer J Cenker, Ryan D Stultz, David McDonald

Open access · greenAbstract read
In one paragraph

Article in AIDS research and human retroviruses, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 95 citations in OpenAlex.

  1. Review
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  8. Dysbiosis modulates CD8iScience · 2025
    Article
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  10. Article
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  13. Review
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  18. Delivering CRISPR to the HIV-1 reservoirs.Frontiers in microbiology · 2024
    Review
  19. Article
  20. Article

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Jennifer J CenkerDepartment of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine , Cleveland, Ohio.
Ryan D StultzDepartment of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine , Cleveland, Ohio.
David McDonaldDepartment of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine , Cleveland, Ohio.
University School · USCase Western Reserve University · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007250 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI HUANG, ALEX YEE-CHEN · 1985 to 2023
$33.4M
NIGMS NIH HHS T32 GM007250
6 · The paper itself

Abstract

Macrophages are a target of human immunodeficiency virus type 1 (HIV-1) infection and may serve as an important reservoir of the virus in the body, particularly after depletion of CD4

Indexed as

Viral TropismCells, CulturedHealthy VolunteersHIV-1HumansMacrophagesMicrogliaSAM Domain and HD Domain-Containing Protein 1SAM Domain and HD Domain-Containing Protein 1SAMHD1 protein, humanHIV-1macrophagemicroglia

Identifiers

PMID28486838
PMCPMC5665495
OpenAlexW2612606194

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.