Trial reportBrain connectivity2017
Altered Network Topology in Patients with Primary Brain Tumors After Fractionated Radiotherapy.
Trial report in Brain connectivity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Graph Theoretical Analysis of Brain Network Characteristics in Brain Tumor Patients: A Systematic Review.Neuropsychology review · 2022Pooled it
- Altered structural networks and cognitive functioning in long-term survivors of pediatric brain tumors.Neuroimage. Reports · 2026Article
- Multiscale network perspectives on glioma: from tumour biology to symptoms, survival and treatment.Nature reviews. Neurology · 2026Review
- Radiotherapy-induced neurocognitive decline among adult intracranial tumor patients: A voxel-based approach.Neuro-oncology · 2025Article
- Article
- Brain network topology and its cognitive impact in adult glioma survivors.Scientific reports · 2024Article
- Strength of spatial correlation between gray matter connectivity and patterns of proto-oncogene and neural network construction gene expression is associated with diffuse glioma survival.Frontiers in neurology · 2024Article
- Graph Theory and Modeling of Network Topology in Clinical Neurosurgery.Advances in experimental medicine and biology · 2024Review
- Strength of spatial correlation between structural brain network connectivity and brain-wide patterns of proto-oncogene and neural network construction gene expression is associated with diffuse glioma survival.medRxiv : the preprint server for health sciences · 2023Article
- Article
- Predicting overall survival in diffuse glioma from the presurgical connectome.Scientific reports · 2022Article
- Article
- Tumor Connectomics: Mapping the Intra-Tumoral Complex Interaction Network Using Machine Learning.Cancers · 2022Article
- Alterations in Functional Connectomics Associated With Neurocognitive Changes Following Glioma Resection.Neurosurgery · 2021Article
- Altered properties of brain white matter structural networks in patients with nasopharyngeal carcinoma after radiotherapy.Brain imaging and behavior · 2020Article
- Alterations of white matter integrity associated with cognitive deficits in patients with glioma.Brain and behavior · 2020Article
- Cognitive phenotypes in temporal lobe epilepsy are associated with distinct patterns of white matter network abnormalities.Neurology · 2019Article
- A Missing Connection: A Review of the Macrostructural Anatomy and Tractography of the Acoustic Radiation.Frontiers in neuroanatomy · 2019Review
- Changing characteristics of the empathic communication network after empathy-enhancement program for medical students.Scientific reports · 2018Article
- Molecular classification of patients with grade II/III glioma using quantitative MRI characteristics.Journal of neuro-oncology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Radiation therapy (RT) is a critical treatment modality for patients with brain tumors, although it can cause adverse effects. Recent data suggest that brain RT is associated with dose-dependent cortical atrophy, which could disrupt neocortical networks. This study examines whether brain RT affects structural network properties in brain tumor patients. We applied graph theory to MRI-derived cortical thickness estimates of 54 brain tumor patients before and after RT. Cortical surfaces were parcellated into 68 regions and correlation matrices were created for patients pre- and post-RT. Significant changes in graph network properties were tested using nonparametric permutation tests. Linear regressions were conducted to measure the association between dose and changes in nodal network connectivity. Increases in transitivity, modularity, and global efficiency (n = 54, p < 0.0001) were all observed in patients post-RT. Decreases in local efficiency (n = 54, p = 0.007) and clustering coefficient (n = 54, p = 0.005) were seen in regions receiving higher RT doses, including the inferior parietal lobule and rostral anterior cingulate. These findings demonstrate alterations in global and local network topology following RT, characterized by increased segregation of brain regions critical to cognition. These pathological network changes may contribute to the late delayed cognitive impairments observed in many patients following brain RT.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.