ReviewNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2017
Beyond Cue Reactivity: Non-Drug-Related Motivationally Relevant Stimuli Are Necessary to Understand Reactivity to Drug-Related Cues.
Review in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it.
- What can case-control comparisons of neural drug cue reactivity tell us about addiction? A neuroimaging meta-analysis.Translational psychiatry · 2026Pooled it
- Personalizing smoking cessation pharmacotherapy using neuroaffective reactivity profiles: A randomized controlled trial.Addiction (Abingdon, England) · 2026Trial
- Bupropion increases activation in nucleus accumbens during anticipation of monetary reward.Psychopharmacology · 2019Trial
- Appetitive startle modulation in the human laboratory predicts Cannabis craving in the natural environment.Psychopharmacology · 2018Trial
- Attentional bias toward emotional and cigarette cues: Insights from a computer mouse-tracking task in adults who smoke and adults who do not smoke.Drug and alcohol dependence · 2026Article
- Methamphetamine potentiates the use of outcome-specific associations via a hypothalamic-dopamine circuit.Neuron · 2026Article
- Repurposing semaglutide as an adjunctive treatment for cocaine use disorder: protocol for a randomised controlled trial.BMJ open · 2026Article
- What a stimulus predicts, not what it depicts, determines striatal reward signals.bioRxiv : the preprint server for biology · 2026Article
- Article
- Profiles of Neuroaffective Responding to Natural Reward-Predicting Cues and Alcohol Images in Alcohol Use Disorder: An Event-Related Potential Approach.bioRxiv : the preprint server for biology · 2025Article
- Comparing the effectiveness of virtual reality vs 2D display-based cue reactivity paradigms to induce nicotine-craving: a behavioral and psychophysiological study.Scientific reports · 2025Article
- Generalized cue reactivity in rat dopamine neurons after opioids.Nature communications · 2025Article
- Using eye tracking to evaluate the impact of smartphone-delivered attentional bias modification training for smokers.Experimental and clinical psychopharmacology · 2024Article
- Variants of the P3 event-related potential operate as indicators of distinct mechanisms contributing to problematic alcohol use.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Blunted sensitivity to expected value during risky decision making in individuals with problematic pornography use.Journal of behavioral addictions · 2024Article
- Testing pharmacotherapies for alcohol use disorder with cue exposure paradigms: A systematic review and quantitative synthesis of human laboratory trial methodology.Alcohol, clinical & experimental research · 2023Review
- Individual differences in late positive potential amplitude and theta power predict cue-induced eating.Addiction neuroscience · 2023Article
- Candidate biomarkers in psychiatric disorders: state of the field.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2023Article
- Neuroaffective reactivity profiles are associated with vulnerability to e-cigarette use.Drug and alcohol dependence · 2023Article
- Towards neuromarkers for tailored smoking cessation treatments.Addiction neuroscience · 2023Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Neurobiological models of addiction posit that drug use can alter reward processes in two ways: (1) by increasing the motivational relevance of drugs and drug-related cues and (2) by reducing the motivational relevance of non-drug-related rewards. Here, we discuss the results from a series of neuroimaging studies in which we assessed the extent to which these hypotheses apply to nicotine dependence. In these studies, we recorded smokers’ and nonsmokers’ brain responses to a wide array of motivationally relevant visual stimuli that included pleasant, unpleasant, cigarette-related, and neutral images. Based on these findings, we highlight the flaws of the traditional cue reactivity paradigm and we conclude that responses to non-drug-related motivationally relevant stimuli should be used to appropriately gauge the motivational relevance of cigarette-related cues and to identify smokers attributing higher motivational relevance to drug-related cues than to non-drug-related rewards. Identifying these individuals is clinically relevant as they achieve lower rates of long-term smoking abstinence when attempting to quit. Finally, we show how this approach may be extended beyond nicotine dependence to inform theoretical and clinical research in the study of obesity. Implications: The cue reactivity paradigm (ie, comparing responses evoked by drug-related cues to those evoked by neutral cues) cannot provide conclusive information about the motivational relevance of drug-related cues. Responses to non-drug-related motivationally relevant stimuli should be used to appropriately gauge the level of motivational relevance that substance-dependent individuals attribute to drug-related cues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.