Evidence map›Paper›PMID 28486651›Full record

ReviewEpidemiologic reviews2017

Vitamin D and Cancer Risk and Mortality: State of the Science, Gaps, and Challenges.

Alison M Mondul, Stephanie J Weinstein, Tracy M Layne, Demetrius Albanes

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Epidemiologic reviews, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
98citing papers in PubMed, 8 pooled it
15.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

98 citing papers in PubMed, 8 syntheses or guidelines pooled it, 178 citations in OpenAlex.

  1. Pooled it
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  4. Vitamin D Deficiency in Testicular Cancer Survivors: A Systematic Review.International journal of molecular sciences · 2021
    Pooled it
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  7. Vitamin D Status and Mortality: A Systematic Review of Observational Studies.International journal of environmental research and public health · 2019
    Pooled it
  8. Dietary and circulating vitamin D and risk of renal cell carcinoma: a meta-analysis of observational studies.International braz j urol : official journal of the Brazilian Society of Urology
    Pooled it
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38 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Alison M Mondul
Stephanie J Weinstein
Tracy M Layne
Demetrius Albanes
Division of Cancer Epidemiology and GeneticsNational Cancer Institute · USUniversity of Michigan–Ann Arbor · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There has been substantial enthusiasm recently regarding the potential role of vitamin D in the primary and secondary prevention of cancer. Laboratory studies demonstrate a range of anticarcinogenic effects for vitamin D compounds, but human studies have yielded little consistent evidence supporting a protective association. Higher circulating levels of vitamin D (i.e., 25-hydroxyvitamin D or 25(OH)D) appear to be associated with reduced risk of colorectal and bladder malignancies, but higher risk of prostate and possibly pancreatic cancers, with no clear association for most other organ sites examined. Despite there being no official institutional recommendations regarding the use of vitamin D supplements for cancer prevention, screenings for vitamin D deficiency and vitamin D supplement use have increased substantially over the past decade. These widespread practices demonstrate that population sociobehavioral changes are often adopted before scientifically well-informed policies and recommendations are available. This review critically examines the currently available epidemiologic literature regarding the associations between circulating 25(OH)D, vitamin D supplementation, and vitamin D-related genetic variation and cancer risk and mortality, with a particular emphasis on prospective studies. We identify several important gaps in our scientific knowledge that should be addressed in order to provide sufficient reproducible data to inform evidence-based recommendations related to optimal 25(OH)D concentrations (and any role for vitamin D supplementation) for the primary and secondary prevention of cancer. With few exceptions, such recommendations cannot be made at this time.

Indexed as

Black PeopleColorectal NeoplasmsDietary SupplementsFemaleHumansMaleNeoplasmsPancreatic NeoplasmsProstatic NeoplasmsProtective FactorsRisk FactorsUrinary Bladder NeoplasmsVitamin DVitamin D Deficiency25-hydroxyvitamin DVitamin Dgeneticsincidencemortalityneoplasmsprospective studiesvitamin D

Identifiers

PMID28486651
PMCPMC5858034
OpenAlexW2612646164

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.