ArticlePloS one2017
Autophagy is a signature of a signaling network that maintains hematopoietic stem cells.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- A mitochondrial surveillance mechanism activated bybioRxiv : the preprint server for biology · 2024Article
- Expansion of human hematopoietic stem cells by inhibiting translation.bioRxiv : the preprint server for biology · 2023Article
- The Tumor SuppressorJournal of developmental biology · 2023Article
- Hematopoietic stem cells preferentially traffic misfolded proteins to aggresomes and depend on aggrephagy to maintain protein homeostasis.Cell stem cell · 2023Article
- Autophagy induction during stem cell activation plays a key role in salivary gland self-renewal.Autophagy · 2022Article
- An Overview of Autophagy in Hematopoietic Stem Cell Transplantation.Frontiers in bioengineering and biotechnology · 2022Review
- Hematopoietic stem cell regulation by the proteostasis network.Current opinion in hematology · 2020Review
- Ex vivo HSC expansion challenges the paradigm of unidirectional human hematopoiesis.Annals of the New York Academy of Sciences · 2020Review
- Article
- Cell-type-specific quantification of protein synthesis in vivo.Nature protocols · 2019Article
- Mitochondrial Role in Stemness and Differentiation of Hematopoietic Stem Cells.Stem cells international · 2019Review
- The clinicopathological significance of ZNF10 in invasive ductal carcinoma of the breast.International journal of clinical and experimental pathology · 2018Article
- Autophagy in Stem Cell Biology: A Perspective on Stem Cell Self-Renewal and Differentiation.Stem cells international · 2018Review
- The Ins and Outs of Autophagy and Metabolism in Hematopoietic and Leukemic Stem Cells: Food for Thought.Frontiers in cell and developmental biology · 2018Review
- Differences of basic and induced autophagic activity between K562 and K562/ADM cells.Intractable & rare diseases research · 2017Article
- Multifaceted Roles of GSK-3 in Cancer and Autophagy-Related Diseases.Oxidative medicine and cellular longevity · 2017Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Hematopoietic stem cells (HSCs) are able to self-renew and to differentiate into all blood cells. HSCs reside in a low-perfusion niche and depend on local signals to survive and to maintain the capacity for self-renewal. HSCs removed from the niche are unable to survive without addition of hematopoietic cytokines and rapidly lose their ability to self-renew. We reported previously that inhibition of both GSK-3 and mTORC1 is essential to maintain long-term HSCs ex vivo. Although Wnt/β-catenin signaling downstream of GSK-3 is required for this response, the downstream effectors of mTORC1 remain undefined. We now report that HSCs express a pro-autophagic gene signature and accumulate LC3 puncta only when both mTORC1 and GSK-3 are inhibited, identifying autophagy as a signature for a signaling network that maintains HSCs ex vivo. In addition, these conditions sustain HSC repopulating function despite an increased rate of global translation. Together, these findings provide new insight into the relative contributions of various mTORC1 outputs toward the maintenance of HSC function and build upon the growing body of literature implicating autophagy and tightly controlled protein synthesis as important modulators of diverse stem cell populations.
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Registered trials
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