ArticlePLoS neglected tropical diseases2017
Migratory phase of Litomosoides sigmodontis filarial infective larvae is associated with pathology and transient increase of S100A9 expressing neutrophils in the lung.
Article in PLoS neglected tropical diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 33 citations in OpenAlex.
- Host environment shapes filarial parasite fitness and Wolbachia endosymbionts dynamics.PLoS pathogens · 2025Article
- Filariasis research - from basic research to drug development and novel diagnostics, over a decade of research at the Institute for Medical Microbiology, Immunology and Parasitology, Bonn, Germany.Frontiers in tropical diseases · 2023Article
- Unbalanced Arginine pathway and altered maturation of pleural macrophages in Th2-deficient mice duringFrontiers in immunology · 2022Article
- NKp46Frontiers in immunology · 2022Article
- Human filariasis-contributions of the Litomosoides sigmodontis and Acanthocheilonema viteae animal model.Parasitology research · 2021Review
- Calprotectin in Lung Diseases.International journal of molecular sciences · 2021Review
- Concurrent Infection With the Filarial HelminthFrontiers in immunology · 2021Article
- Microfilaria-dependent thoracic pathology associated with eosinophilic and fibrotic polyps in filaria-infected rodents.Parasites & vectors · 2020Article
- The immune response of inbred laboratory mice to Litomosoides sigmodontis: A route to discovery in myeloid cell biology.Parasite immunology · 2020Review
- Oxfendazole mediates macrofilaricidal efficacy against the filarial nematode Litomosoides sigmodontis in vivo and inhibits Onchocerca spec. motility in vitro.PLoS neglected tropical diseases · 2020Article
- Limited role of mast cells during infection with the parasitic nematode Litomosoides sigmodontis.PLoS neglected tropical diseases · 2020Article
- Semaphorin 3F signaling actively retains neutrophils at sites of inflammation.The Journal of clinical investigation · 2020Article
- Comparison of immune responses to Loa loa stage-specific antigen extracts in Loa loa-exposed BALB/c mice upon clearance of infection.Parasites & vectors · 2020Article
- S100A8/S100A9 deficiency increases neutrophil activation and protective immune responses against invading infective L3 larvae of the filarial nematode Litomosoides sigmodontis.PLoS neglected tropical diseases · 2020Article
- Adjuvant-free immunization with infective filarial larvae as lymphatic homing antigen carriers.Scientific reports · 2020Article
- Comparative analysis of small RNAs released by the filarial nematode Litomosoides sigmodontis in vitro and in vivo.PLoS neglected tropical diseases · 2019Article
- The liver proteome in a mouse model for Ascaris suum resistance and susceptibility: evidence for an altered innate immune response.Parasites & vectors · 2019Article
- IL-4 receptor dependent expansion of lung CD169+ macrophages in microfilaria-driven inflammation.PLoS neglected tropical diseases · 2019Article
- In vivo kinetics of Wolbachia depletion by ABBV-4083 in L. sigmodontis adult worms and microfilariae.PLoS neglected tropical diseases · 2019Article
- Inherent biomechanical traits enable infective filariae to disseminate through collecting lymphatic vessels.Nature communications · 2019Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 5 countries.
Funding
Abstract
Filarial infections are tropical diseases caused by nematodes of the Onchocercidae family such as Mansonella perstans. The infective larvae (L3) are transmitted into the skin of vertebrate hosts by blood-feeding vectors. Many filarial species settle in the serous cavities including M. perstans in humans and L. sigmodontis, a well-established model of filariasis in mice. L. sigmodontis L3 migrate to the pleural cavity where they moult into L4 around day 9 and into male and female adult worms around day 30. Little is known of the early phase of the parasite life cycle, after the L3 is inoculated in the dermis by the vector and enters the afferent lymphatic vessels and before the moulting processes in the pleural cavity. Here we reveal a pulmonary phase associated with lung damage characterized by haemorrhages and granulomas suggesting L3 reach the lung via pulmonary capillaries and damage the endothelium and parenchyma by crossing them to enter the pleural cavity. This study also provides evidence for a transient inflammation in the lung characterized by a very early recruitment of neutrophils associated with high expression levels of S100A8 and S100A9 proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.