Evidence map›Paper›PMID 28486423›Full record

ArticleInternational journal of environmental research and public health2017

Association between Pesticide Profiles Used on Agricultural Fields near Maternal Residences during Pregnancy and IQ at Age 7 Years.

Eric Coker, Robert Gunier, Asa Bradman, Kim Harley, Katherine Kogut, John Molitor, Brenda Eskenazi

Abstract read
In one paragraph

Article in International journal of environmental research and public health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Eric CokerSchool of Public Health, University of California, Berkeley, CA 94703, USA. eric.coker@berkeley.edu.
Robert GunierSchool of Public Health, University of California, Berkeley, CA 94703, USA. gunier@berkeley.edu.
Asa BradmanSchool of Public Health, University of California, Berkeley, CA 94703, USA. abradman@berkeley.edu.
Kim HarleySchool of Public Health, University of California, Berkeley, CA 94703, USA. kharley@berkeley.edu.
Katherine KogutSchool of Public Health, University of California, Berkeley, CA 94703, USA. kkogut8@berkeley.edu.
John MolitorCollege of Public Health and Human Sciences, Oregon State University, Corvallis, OR 97331, USA. john.molitor@oregonstate.edu.
Brenda EskenaziSchool of Public Health, University of California, Berkeley, CA 94703, USA. eskenazi@berkeley.edu.

Funding

Research Mentoring and Building Capacity of underrepresented Minority Research Scientists in India.D43TW010540 · FIC · YALE UNIVERSITY · PI MICHELE BARRY, Eva Harris · 2017 to 2026
$15.5M
Project C: Epigenetic Effects of DDT/E and PBDEs on PubertyP01ES009605 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ESKENAZI, BRENDA · 1999 to 2015
$11.2M
FIC NIH HHS D43 TW010540NIEHS NIH HHS P01 ES009605
6 · The paper itself

Abstract

We previously showed that potential prenatal exposure to agricultural pesticides was associated with adverse neurodevelopmental outcomes in children, yet the effects of joint exposure to multiple pesticides is poorly understood. In this paper, we investigate associations between the joint distribution of agricultural use patterns of multiple pesticides (denoted as "pesticide profiles") applied near maternal residences during pregnancy and Full-Scale Intelligence Quotient (FSIQ) at 7 years of age. Among a cohort of children residing in California's Salinas Valley, we used Pesticide Use Report (PUR) data to characterize potential exposure from use within 1 km of maternal residences during pregnancy for 15 potentially neurotoxic pesticides from five different chemical classes. We used Bayesian profile regression (BPR) to examine associations between clustered pesticide profiles and deficits in childhood FSIQ. BPR identified eight distinct clusters of prenatal pesticide profiles. Two of the pesticide profile clusters exhibited some of the highest cumulative pesticide use levels and were associated with deficits in adjusted FSIQ of -6.9 (95% credible interval: -11.3, -2.2) and -6.4 (95% credible interval: -13.1, 0.49), respectively, when compared with the pesticide profile cluster that showed the lowest level of pesticides use. Although maternal residence during pregnancy near high agricultural use of multiple neurotoxic pesticides was associated with FSIQ deficit, the magnitude of the associations showed potential for sub-additive effects. Epidemiologic analysis of pesticides and their potential health effects can benefit from a multi-pollutant approach to analysis.

Indexed as

AdultBayes TheoremCaliforniaChildEnvironmental ExposureFemaleHumansIntelligence TestsPesticidesPregnancyPrenatal Exposure Delayed EffectsPesticidescarbamatesmixturesneurodevelopmentorganophosphatespesticidespyrethroids

Identifiers

PMID28486423
PMCPMC5451957

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.