ArticleMenopause (New York, N.Y.)2017
Menopause and postmenopausal hormone therapy and risk of hearing loss.
Article in Menopause (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 48 citations in OpenAlex.
- Association of Menopause and Hormone Replacement Therapy with Hearing Loss.The Annals of otology, rhinology, and laryngology · 2026Article
- Estrogen Exposure is Associated With Reduced Otosclerosis Risk in Obesity and Hormone Therapy.Otology & neurotology open · 2026Article
- A plasma metabolomic fingerprint of moderate or severe hearing loss.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Association between serum iron levels and low-frequency hearing loss in Korean females.Annals of occupational and environmental medicine · 2025Article
- Gonad-derived steroid hormones mediate a sex difference in the maturation of auditory encoding in the cochlea from adolescence to early adulthood in C57BL/6J mice.Hearing research · 2025Article
- Association Between Obstructive Sleep Apnea and Hearing Loss Using 2019-2021 Korea National Health and Nutrition Examination Survey Data.The journal of international advanced otology · 2025Article
- Sex differences in the pleiotropy of hearing difficulty with imaging-derived phenotypes: a brain-wide investigation.Brain : a journal of neurology · 2024Article
- Correlation between Hearing Impairment and the Triglyceride Glucose Index in Middle-Aged Female Based on a Korean National Health and Nutrition Examination Survey.Medicina (Kaunas, Lithuania) · 2024Article
- An Observational Study of Hearing Loss Among Menopausal Women.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024Article
- Age-related hearing loss: An updated and comprehensive review of the interventions.Iranian journal of basic medical sciences · 2024Review
- Correlation between hearing impairment and the Triglyceride Glucose Index: based on a national cross-sectional study.Frontiers in endocrinology · 2023Article
- [Hormone replacement therapy in perimenopausal women with chronic tinnitus].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2021Article
- Sex Differences in Otolaryngology: Focus on the Emerging Role of Estrogens in Inflammatory and Pro-Resolving Responses.International journal of molecular sciences · 2021Review
- Sex Differences in the Triad of Acquired Sensorineural Hearing Loss.International journal of molecular sciences · 2021Review
- Age-related hearing loss pertaining to potassium ion channels in the cochlea and auditory pathway.Pflugers Archiv : European journal of physiology · 2021Review
- Do Women Have Better Hearing Than Men?Clinical and experimental otorhinolaryngology · 2021Article
- Hearing Loss and Cognition: What We Know and Where We Need to Go.Frontiers in aging neuroscience · 2021Review
- Cigarette Smoking, Smoking Cessation, and Risk of Hearing Loss in Women.The American journal of medicine · 2020Article
- Associations of Hearing Loss and Menopausal Hormone Therapy With Change in Global Cognition and Incident Cognitive Impairment Among Postmenopausal Women.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Auditory function and dysfunction: estrogen makes a difference.Cellular and molecular life sciences : CMLS · 2020Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveMenopause may be a risk factor for hearing loss, and postmenopausal hormone therapy (HT) has been proposed to slow hearing decline; however, there are no large prospective studies. We prospectively examined the independent relations between menopause and postmenopausal HT and risk of self-reported hearing loss.
methodsProspective cohort study among 80,972 women in the Nurses' Health Study II, baseline age 27 to 44 years, followed from 1991 to 2013. Baseline and updated information was obtained from detailed validated biennial questionnaires. Cox proportional-hazards regression models were used to examine independent associations between menopausal status and postmenopausal HT and risk of hearing loss.
resultsAfter 1,410,928 person-years of follow-up, 18,558 cases of hearing loss were reported. There was no significant overall association between menopausal status, natural or surgical, and risk of hearing loss. Older age at natural menopause was associated with higher risk. The multivariable-adjusted relative risk of hearing loss among women who underwent natural menopause at age 50+ years compared with those aged less than 50 years was 1.10 (95% confidence interval [CI] 1.03, 1.17). Among postmenopausal women, oral HT (estrogen therapy or estrogen plus progestogen therapy) was associated with higher risk of hearing loss, and longer duration of use was associated with higher risk (P trend < 0.001). Compared with women who never used HT, the multivariable-adjusted relative risk of hearing loss among women who used oral HT for 5 to 9.9 years was 1.15 (95% CI 1.06, 1.24) and for 10+ years was 1.21 (95% CI 1.07, 1.37).
conclusionsOlder age at menopause and longer duration of postmenopausal HT are associated with higher risk of hearing loss.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.