ArticlePsychoneuroendocrinology2017
Depressive symptom profiles, cardio-metabolic risk and inflammation: Results from the MIDUS study.
Article in Psychoneuroendocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Evaluating the Impact of the Prime Time Sister CirclesJournal of general internal medicine · 2023Trial
- Cardio-metabolic risk among healthcare providers: A latent profile study.Journal of cardiovascular and thoracic research · 2025Article
- C-reactive protein is not a biomarker of depression severity in drug-naïve obese patients with metabolic syndrome.Acta neuropsychiatrica · 2025Article
- Associations between Recession Hardships and Subjective and Objective Sleep Measures in the Midlife in the United States Study: Race and Gender Differences.Frontiers in sleep · 2024Article
- Depressive Symptom Subgroups and Their Association with Prevalent and Incident Cardiovascular Risk Factors in the Coronary Artery Risk Development in Young Adults (CARDIA) Study.International journal of behavioral medicine · 2023Article
- Mediation of the Association Between Vascular Risk Factors and Depressive Symptoms by C-Reactive Protein.Biological psychiatry global open science · 2023Article
- Psychosocial profiles and longitudinal achievement of optimal cardiovascular risk factor levels: the Coronary Artery Risk Development in Young Adults (CARDIA) study.Journal of behavioral medicine · 2022Article
- Serial Mediation Roles of Perceived Stress and Depressive Symptoms in the Association Between Sleep Quality and Life Satisfaction Among Middle-Aged American Adults.Frontiers in psychology · 2022Article
- Association between single and multiple cardiometabolic diseases and depression: A cross-sectional study of 391,083 participants from the UK biobank.Frontiers in public health · 2022Article
- Associations Between Child Maltreatment, Inflammation, and Comorbid Metabolic Syndrome to Depressed Mood in a Multiethnic Urban Population: The HELIUS Study.Frontiers in psychology · 2022Article
- Association between serum sphingolipids and eudaimonic well-being in white U.S. adults.Scientific reports · 2021Article
- The Metabolomic Underpinnings of Symptom Burden in Patients With Multiple Chronic Conditions.Biological research for nursing · 2021Article
- Linking discrimination and sleep with biomarker profiles: An investigation in the MIDUS study.Comprehensive psychoneuroendocrinology · 2021Article
- Depression-, Anxiety-, and Anger and Cognitive Functions: Findings From a Longitudinal Prospective Study.Frontiers in psychiatry · 2021Article
- The common denominators of sleep, obesity, and psychopathology.Current opinion in psychology · 2020Review
- Common and specific dimensions of internalizing disorders are characterized by unique patterns of brain activity on a task of emotional cognitive control.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2020Article
- High social strain and physical health: Examining the roles of anxious arousal, body mass index, and inflammation.Psychoneuroendocrinology · 2019Article
- Latent profile analysis of anxiety disorder among left-behind children in rural Southern China: a cross-sectional study.BMJ open · 2019Article
- Article
- Nucleus accumbens inflammation mediates anxiodepressive behavior and compulsive sucrose seeking elicited by saturated dietary fat.Molecular metabolism · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundThis study aimed to (1) provide a comprehensive characterization of depressive symptoms profiles, and (2) examine the cross-sectional association between depressive symptom profiles and cardio-metabolic outcomes, including metabolic syndrome and obesity, while controlling for sociodemographic variables, health behaviors and inflammation.
methodsOur sample was comprised of 1085 participants (55.80% female) enrolled in the MIDUS-II biomarker study. Latent profile analysis (LPA) was used to derive depressive symptom profiles using subscales of the Mood and Anxiety Symptom Questionnaire (MASQ) and the Center for Epidemiologic Studies Depression Scale (CES-D) subscales as well as Pittsburgh Sleep Quality Index (PSQI) global score. Metabolic syndrome was defined according to the Interim Joint Statement definition. CRP was used as a marker of inflammation.
resultsFour depressive symptom profiles were identified. The "No Symptoms" subgroup (60.65% of the sample) had the lowest overall scores across subscales. The "Mild Symptoms" subgroup (26.73%) was characterized by lower scores across indicators, with subscales measuring somatic symptoms being the highest within group. The "Moderate Symptoms" subgroup (10.32%) had higher scores across subscales (1 SD above the mean), with subscales measuring negative affect/loss of interest being the highest within group. Finally, the "Acute symptoms" subgroup (2.30%) was characterized by the highest overall scores (1.5-3 SD above the mean) on all indicators. After controlling for sociodemographic characteristics and health behaviors, the "Moderate Symptoms" subgroup was significantly associated with metabolic syndrome (OR=1.595, p=0.035) and obesity (OR=1.555, p=0.046). Further, there was a trend between the "Mild Symptoms" subgroup and the presence of obesity (OR=1.345, p=0.050). Inflammation attenuated these associations.
conclusionsFour depressive symptom profiles were identified among healthy mid-life individuals in the US. These profiles are differentially associated with cardio-metabolic outcomes. Future work should examine whether distinct symptom profiles may reflect differential pathways to increased risk, and whether tailored management of symptoms is needed.
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