Evidence map›Paper›PMID 28486147›Full record

ArticleBiomaterials2017

Multimodal assessment of SERS nanoparticle biodistribution post ingestion reveals new potential for clinical translation of Raman imaging.

Jos L Campbell, Elliott D SoRelle, Ohad Ilovich, Orly Liba, Michelle L James, Zhen Qiu, Valerie Perez, Carmel T Chan, Adam de la Zerda, Cristina Zavaleta

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
5.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Review
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  6. Article
  7. Review
  8. Design and Synthesis of SERS Materials for In Vivo Molecular Imaging and Biosensing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Review
  9. Nanomaterial-based contrast agents.Nature reviews. Methods primers · 2023
    Article
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  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 2 countries.

Jos L CampbellMolecular Imaging Program at Stanford University, 318 Campus Dr., Stanford, CA 94305, United States; RMIT University, 124 Latrobe St, Melbourne, Victoria 3000, Australia; Department of Radiology, Stanford University, 1201 Welch Rd., Stanford, CA 94305, United States.
Elliott D SoRelleMolecular Imaging Program at Stanford University, 318 Campus Dr., Stanford, CA 94305, United States; Biophysics Program, Stanford University, 291 Campus Dr., Stanford, CA 94305, United States; Department of Structural Biology, Stanford University, 299 Campus Dr., Stanford, CA 94305, United States.
Ohad IlovichMolecular Imaging Program at Stanford University, 318 Campus Dr., Stanford, CA 94305, United States; Department of Radiology, Stanford University, 1201 Welch Rd., Stanford, CA 94305, United States; inviCRO, LLC, Imaging Services and Software, 27 Drydock Ave., Boston, MA 02210, United States.
Orly LibaMolecular Imaging Program at Stanford University, 318 Campus Dr., Stanford, CA 94305, United States; Department of Electrical Engineering, Stanford University, 350 Serra Mall, Stanford, CA 94305, United States.
Michelle L JamesMolecular Imaging Program at Stanford University, 318 Campus Dr., Stanford, CA 94305, United States; Department of Radiology, Stanford University, 1201 Welch Rd., Stanford, CA 94305, United States.
Zhen QiuMolecular Imaging Program at Stanford University, 318 Campus Dr., Stanford, CA 94305, United States; Department of Radiology, Stanford University, 1201 Welch Rd., Stanford, CA 94305, United States; Department of Pediatrics, 300 Pasteur Dr. H310, Stanford, CA 94305, United States.
Valerie PerezMolecular Imaging Program at Stanford University, 318 Campus Dr., Stanford, CA 94305, United States; Department of Radiology, Stanford University, 1201 Welch Rd., Stanford, CA 94305, United States; Department of Chemical Engineering, Stanford University, 443 Via Ortega, Stanford, CA 94305, United States.
Carmel T ChanMolecular Imaging Program at Stanford University, 318 Campus Dr., Stanford, CA 94305, United States; Department of Radiology, Stanford University, 1201 Welch Rd., Stanford, CA 94305, United States.
Adam de la ZerdaMolecular Imaging Program at Stanford University, 318 Campus Dr., Stanford, CA 94305, United States; Biophysics Program, Stanford University, 291 Campus Dr., Stanford, CA 94305, United States; Department of Structural Biology, Stanford University, 299 Campus Dr., Stanford, CA 94305, United States; Department of Electrical Engineering, Stanford University, 350 Serra Mall, Stanford, CA 94305, United States.
Cristina ZavaletaMolecular Imaging Program at Stanford University, 318 Campus Dr., Stanford, CA 94305, United States; Department of Radiology, Stanford University, 1201 Welch Rd., Stanford, CA 94305, United States. Electronic address: czavalet@stanford.edu.
Stanford University · US

Funding

A New Strategy for Cancer Detection using Raman Spectroscopy with NanoparticlesK22CA160834 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ZAVALETA, CRISTINA L. · 2014 to 2016
$582k
A New Raman-based Strategy to Identify Tumor Margins and Guide Surgical ResectionR21CA184608 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ZAVALETA, CRISTINA L. · 2015 to 2016
$368k
NCI NIH HHS K22 CA160834NCI NIH HHS R21 CA184608
6 · The paper itself

Abstract

Despite extensive research and development, new nano-based diagnostic contrast agents have faced major barriers in gaining regulatory approval due to their potential systemic toxicity and prolonged retention in vital organs. Here we use five independent biodistribution techniques to demonstrate that oral ingestion of one such agent, gold-silica Raman nanoparticles, results in complete clearance with no systemic toxicity in living mice. The oral delivery mimics topical administration to the oral cavity and gastrointestinal (GI) tract as an alternative to intravenous injection. Biodistribution and clearance profiles of orally (OR) vs. intravenously (IV) administered Raman nanoparticles were assayed over the course of 48 h. Mice given either an IV or oral dose of Raman nanoparticles radiolabeled with approximately 100 μCi (3.7MBq) of

Indexed as

AnimalsFemaleMiceMice, NudeMultimodal ImagingNanoparticlesPositron-Emission TomographySpectrum Analysis, RamanBiodistributionMicroPETRaman imagingSERS nanoparticlesSystemic toxicity

Identifiers

PMID28486147
PMCPMC6252087
OpenAlexW2609364533

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.