ArticleDevelopmental cell2017
Gastric Acid Secretion from Parietal Cells Is Mediated by a Ca
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Article in Developmental cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33citing papers in PubMed
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33 citing papers in PubMed, 57 citations in OpenAlex.
- Oxytocin receptor signaling contributes to the mitochondrial integrity and maintain gastric mucosal homeostasis in male mice.iScience · 2026Article
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- Gastric Proton Pumpopathy Associated with Protein Sorting Machinery: A Narrative Review.Clinical and experimental gastroenterology · 2026Review
- Physiological functions and pharmacological targeting of transient receptor potential channels.Pharmacological reviews · 2025Review
- TRPML2 in distinct states reveals the activation and modulation principles of the TRPML family.Nature communications · 2025Article
- Activation of the TRPML1 Ion Channel Induces Proton Secretion in the Human Gastric Parietal Cell Line HGT-1.International journal of molecular sciences · 2024Article
- MCOLN1/TRPML1 in the lysosome: a promising target for autophagy modulation in diverse diseases.Autophagy · 2024Review
- The ion channels of endomembranes.Physiological reviews · 2024Review
- Exosomes derived from tumor adjacent fibroblasts efficiently target pancreatic tumors.Acta pharmaceutica Sinica. B · 2024Article
- Electrophysiological Techniques on the Study of Endolysosomal Ion Channels.Handbook of experimental pharmacology · 2023Article
- Intracellular CaFrontiers in physiology · 2023Review
- GCAF(TMEM251) regulates lysosome biogenesis by activating the mannose-6-phosphate pathway.Nature communications · 2022Article
- Autophagy inhibition mediated by MCOLN1/TRPML1 suppresses cancer metastasis via regulating a ROS-driven TP53/p53 pathway.Autophagy · 2022Article
- Elevated Protein Kinase A Activity in Stomach Mesenchyme Disrupts Mesenchymal-epithelial Crosstalk and Induces Preneoplasia.Cellular and molecular gastroenterology and hepatology · 2022Article
- MCOLN1/TRPML1 finely controls oncogenic autophagy in cancer by mediating zinc influx.Autophagy · 2021Article
- Lysosomal ZnCell reports · 2021Article
- TRP channels in health and disease at a glance.Journal of cell science · 2021Article
- Estradiol analogs attenuate autophagy, cell migration and invasion by direct and selective inhibition of TRPML1, independent of estrogen receptors.Scientific reports · 2021Article
- Lysosomal Calcium Channels in Autophagy and Cancer.Cancers · 2021Review
- Endolysosomal TRPMLs in Cancer.Biomolecules · 2021Review
Corrections and comments
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Authors and funding
21 authors at 2 institutions in 2 countries.
Nirakar SahooDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, 3089 Natural Science Building (Kraus), 830 North University, Ann Arbor, MI 48109, USA.
Mingxue GuDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, 3089 Natural Science Building (Kraus), 830 North University, Ann Arbor, MI 48109, USA.
Xiaoli ZhangDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, 3089 Natural Science Building (Kraus), 830 North University, Ann Arbor, MI 48109, USA.
Neel RavalDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, 3089 Natural Science Building (Kraus), 830 North University, Ann Arbor, MI 48109, USA.
Junsheng YangDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, 3089 Natural Science Building (Kraus), 830 North University, Ann Arbor, MI 48109, USA; Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China.
Michael BekierDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, 3089 Natural Science Building (Kraus), 830 North University, Ann Arbor, MI 48109, USA.
Raul CalvoNational Center for Advancing Translational Sciences, National Institute of Health, 9800 Medical Center Drive, Rockville, MD 20850, USA.
Samarjit PatnaikNational Center for Advancing Translational Sciences, National Institute of Health, 9800 Medical Center Drive, Rockville, MD 20850, USA.
Wuyang WangDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, 3089 Natural Science Building (Kraus), 830 North University, Ann Arbor, MI 48109, USA.
Greyson KingDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, 3089 Natural Science Building (Kraus), 830 North University, Ann Arbor, MI 48109, USA.
Mohammad SamieDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, 3089 Natural Science Building (Kraus), 830 North University, Ann Arbor, MI 48109, USA.
Qiong GaoDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, 3089 Natural Science Building (Kraus), 830 North University, Ann Arbor, MI 48109, USA.
Sasmita SahooDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, 3089 Natural Science Building (Kraus), 830 North University, Ann Arbor, MI 48109, USA.
Sinju SundaresanDivision of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Theresa M KeeleyDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
Yanzhuang WangDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, 3089 Natural Science Building (Kraus), 830 North University, Ann Arbor, MI 48109, USA.
Juan MaruganNational Center for Advancing Translational Sciences, National Institute of Health, 9800 Medical Center Drive, Rockville, MD 20850, USA.
Marc FerrerNational Center for Advancing Translational Sciences, National Institute of Health, 9800 Medical Center Drive, Rockville, MD 20850, USA.
Linda C SamuelsonDivision of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
Juanita L MerchantDivision of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Haoxing XuDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, 3089 Natural Science Building (Kraus), 830 North University, Ann Arbor, MI 48109, USA. Electronic address: haoxingx@umich.edu.
University of Michigan–Ann Arbor · USNational Center for Advancing Translational Sciences · US
Funding
University of Michigan Center for Gastrointestinal ResearchP30DK034933 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OWYANG, CHUNG · 1986 to 2021
$22.5MRole of Hedgehog Signaling in Chronic Gastritis and MetaplasiaP01DK062041 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MERCHANT, JUANITA L. · 2002 to 2017
$20.6MTranscriptional Control of GastrinR37DK045729 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MERCHANT, JUANITA L. · 2007 to 2016
$3.4MThe Mucolipin TRP Ion ChannelsR01NS062792 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI XU, HAOXING · 2009 to 2018
$3.3MGOLGI MATRIX ASSEMBLY AND DISASSEMBLY IN THE CELL CYCLER01GM105920 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ANDREWS, PHILIP C, WANG, YANZHUANG · 2014 to 2017
$1.9MTRP Ca2+ Channels in the SkinR01AR060837 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI XU, HAOXING · 2012 to 2016
$1.7MSupplement: GOLGI BIOGENESIS AND FUNCTIONR01GM112786 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WANG, YANZHUANG · 2015 to 2019
$1.3MNIAMS NIH HHS R01 AR060837NIDDK NIH HHS P01 DK062041NIDDK NIH HHS P30 DK034933NIDDK NIH HHS R37 DK045729NIGMS NIH HHS R01 GM105920NIGMS NIH HHS R01 GM112786NINDS NIH HHS R01 NS062792
Abstract
Gastric acid secretion by parietal cells requires trafficking and exocytosis of H/K-ATPase-rich tubulovesicles (TVs) toward apical membranes in response to histamine stimulation via cyclic AMP elevation. Here, we found that TRPML1 (ML1), a protein that is mutated in type IV mucolipidosis (ML-IV), is a tubulovesicular channel essential for TV exocytosis and acid secretion. Whereas ML-IV patients are reportedly achlorhydric, transgenic overexpression of ML1 in mouse parietal cells induced constitutive acid secretion. Gastric acid secretion was blocked and stimulated by ML1 inhibitors and agonists, respectively. Organelle-targeted Ca
Indexed as
AnimalsBiological TransportCalciumCell MembraneExocytosisGastric AcidHistamineH(+)-K(+)-Exchanging ATPaseMiceParietal Cells, GastricSignal TransductionCalciumHistamineH(+)-K(+)-Exchanging ATPaseCa(2+) releasecAMPexocytosismembrane traffickingTRPML1tubulovesicle
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.