Evidence map›Paper›PMID 28486109›Full record

ArticleCancer cell2017

Tumor-Residing Batf3 Dendritic Cells Are Required for Effector T Cell Trafficking and Adoptive T Cell Therapy.

Stefani Spranger, Daisy Dai, Brendan Horton, Thomas F Gajewski

Abstract read
In one paragraph

Article in Cancer cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 929 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
929citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

929 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Phase II Trial of Pembrolizumab in Combination With Bevacizumab for Untreated Melanoma Brain Metastases.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2025
    Trial
  4. Article
  5. Review
  6. Article
  7. Article
  8. Evidence-steered medicine in oncology: network-aware micro-combinations that safeguard standard of care and potentially improve benefit-risk.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

869 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Stefani SprangerDepartment of Pathology, The University of Chicago, 5841 South Maryland Avenue, MC2115, Chicago, IL 60637, USA.
Daisy DaiDepartment of Pathology, The University of Chicago, 5841 South Maryland Avenue, MC2115, Chicago, IL 60637, USA.
Brendan HortonDepartment of Pathology, The University of Chicago, 5841 South Maryland Avenue, MC2115, Chicago, IL 60637, USA.
Thomas F GajewskiDepartment of Pathology, The University of Chicago, 5841 South Maryland Avenue, MC2115, Chicago, IL 60637, USA; Department of Medicine, The University of Chicago, 5841 South Maryland Avenue, MC2115, Chicago, IL 60637, USA. Electronic address: tgajewsk@medicine.bsd.uchicago.edu.

Funding

Overcoming resistance to anti-PD1 immunotherapyR35CA210098 · NCI · UNIVERSITY OF CHICAGO · PI THOMAS F GAJEWSKI · 2017 to 2026
$10.4M
Tumor-intrinsic oncogenic alterations and evasion of anti-tumor immunityR00CA204595 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SPRANGER, STEFANI · 2017 to 2019
$747k
Germline and somatic variants associated with melanoma immunophenotypeR01CA198496 · NCI · UNIVERSITY OF CHICAGO · PI GAJEWSKI, THOMAS F · 2016 to 2016
$433k
Tumor-intrinsic oncogenic alterations and evasion of anti-tumor immunityK99CA204595 · NCI · UNIVERSITY OF CHICAGO · PI SPRANGER, STEFANI · 2016 to 2017
$147k
NCI NIH HHS K99 CA204595NCI NIH HHS R00 CA204595NCI NIH HHS R01 CA198496NCI NIH HHS R35 CA210098
6 · The paper itself

Abstract

Effector T cells have the capability of recognizing and killing cancer cells. However, whether tumors can become immune resistant through exclusion of effector T cells from the tumor microenvironment is not known. By using a tumor model resembling non-T cell-inflamed human tumors, we assessed whether adoptive T cell transfer might overcome failed spontaneous priming. Flow cytometric assays combined with intra-vital imaging indicated failed trafficking of effector T cells into tumors. Mechanistically, this was due to the absence of CXCL9/10, which we found to be produced by CD103

Indexed as

Chemotaxis, LeukocyteTumor EscapeAnimalsAntigens, CDBasic-Leucine Zipper Transcription Factorsbeta CateninCD8-Positive T-LymphocytesCell Line, TumorCell ProliferationChemokine CXCL10Chemokine CXCL9Dendritic CellsGenotypeImmunologic MemoryImmunotherapy, AdoptiveIntegrin alpha Chainsalpha E integrinsAntigens, CDBasic-Leucine Zipper Transcription FactorsBATF3 protein, humanbeta CateninChemokine CXCL10Chemokine CXCL9CTNNB1 protein, mouseCxcl10 protein, mouseCxcl9 protein, mouseIntegrin alpha ChainsRepressor ProteinsSNFT protein, mouseadoptive T cell transferimmune escapeimmunotherapy resistancenon-T cell-inflamed tumor microenvironmentT cell-inflamed tumor microenvironment

Identifiers

PMID28486109
PMCPMC5650691

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.