ArticleTranslational psychiatry2017
The effect of crack cocaine addiction and age on the microstructure and morphology of the human striatum and thalamus using shape analysis and fast diffusion kurtosis imaging.
Article in Translational psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Gray and white matter morphology in substance use disorders: a neuroimaging systematic review and meta-analysis.Translational psychiatry · 2021Pooled it
- An explainable multimodal artificial intelligence model for classifying suicide attempters with borderline personality disorder: a pilot study.Scientific reports · 2025Article
- Adolescent substance use initiation and long-term neurobiological outcomes: insights, challenges and opportunities.Molecular psychiatry · 2024Review
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- The effects of locus coeruleus ablation on mouse brain volume and microstructure evaluated by high-field MRI.Frontiers in cellular neuroscience · 2024Article
- Neuroimaging and immunological features of neurocognitive function related to substance use in people with HIV.Journal of neurovirology · 2023Article
- Lower cortical thickness and increased brain aging in adults with cocaine use disorder.Frontiers in psychiatry · 2023Article
- Music and Brain Circuitry: Strategies for Strengthening Evidence-Based Research for Music-Based Interventions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Review
- Aberrant cortico-striatal white matter connectivity and associated subregional microstructure of the striatum in obsessive-compulsive disorder.Molecular psychiatry · 2022Article
- Assessment of brain connectome alterations in male chronic smokers using structural and generalized q-sampling MRI.Brain imaging and behavior · 2022Article
- The Mexican magnetic resonance imaging dataset of patients with cocaine use disorder: SUDMEX CONN.Scientific data · 2022Article
- Diffusion Abnormality in Temporal Lobe Epilepsy Patients With Sleep Disorders: A Diffusion Kurtosis Imaging Study.Frontiers in psychiatry · 2022Article
- Toward more robust and reproducible diffusion kurtosis imaging.Magnetic resonance in medicine · 2021Article
- Neuroanatomical underpinning of diffusion kurtosis measurements in the cerebral cortex of healthy macaque brains.Magnetic resonance in medicine · 2021Article
- Audiovisual structural connectivity in musicians and non-musicians: a cortical thickness and diffusion tensor imaging study.Scientific reports · 2021Article
- Article
- Characterizing the Subcortical Structures in Youth with Congenital Heart Disease.AJNR. American journal of neuroradiology · 2020Article
- Interactive effects of age and recent substance use on striatal shape morphology at substance use disorder treatment entry.Drug and alcohol dependence · 2020Article
- Diffusion Kurtosis Imaging of Microstructural Changes in Gray Matter Nucleus in Parkinson Disease.Frontiers in neurology · 2020Article
- Diffusion Kurtosis Imaging as a Tool in Neurotoxicology.Neurotoxicity research · 2020Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The striatum and thalamus are subcortical structures intimately involved in addiction. The morphology and microstructure of these have been studied in murine models of cocaine addiction (CA), showing an effect of drug use, but also chronological age in morphology. Human studies using non-invasive magnetic resonance imaging (MRI) have shown inconsistencies in volume changes, and have also shown an age effect. In this exploratory study, we used MRI-based volumetric and novel shape analysis, as well as a novel fast diffusion kurtosis imaging sequence to study the morphology and microstructure of striatum and thalamus in crack CA compared to matched healthy controls (HCs), while investigating the effect of age and years of cocaine consumption. We did not find significant differences in volume and mean kurtosis (MKT) between groups. However, we found significant contraction of nucleus accumbens in CA compared to HCs. We also found significant age-related changes in volume and MKT of CA in striatum and thalamus that are different to those seen in normal aging. Interestingly, we found different effects and contributions of age and years of consumption in volume, displacement and MKT changes, suggesting that each measure provides different but complementing information about morphological brain changes, and that not all changes are related to the toxicity or the addiction to the drug. Our findings suggest that the use of finer methods and sequences provides complementing information about morphological and microstructural changes in CA, and that brain alterations in CA are related cocaine use and age differently.
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