ArticleTranslational psychiatry2017
Sensory integration deficits support a dimensional view of psychosis and are not limited to schizophrenia.
Article in Translational psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- A Systematic Review and Meta-Analysis on Contrast Sensitivity in Schizophrenia.Schizophrenia bulletin · 2025Pooled it
- Mapping the psychosis spectrum - imaging neurosubtypes from multiscale functional network connectivity.Molecular psychiatry · 2026Article
- Transdiagnostic alterations of intrinsic brain activity in major psychiatric disorders.European archives of psychiatry and clinical neuroscience · 2026Article
- Cortical Structures Underlying Schizophrenia and Sex Differences in Preadolescents: An Adolescent Brain Cognitive Development Study.Child psychiatry and human development · 2026Article
- Disrupted hierarchical functional brain organization in affective and psychotic disorders: insights from functional brain gradients.Translational psychiatry · 2026Article
- Acute technostress, schizotypal traits, and visual illusion perception in the general population.Experimental brain research · 2026Article
- Neural fingerprints of data driven cognitive subtypes across the psychosis spectrum: a B-SNIP study.Translational psychiatry · 2025Article
- Visual integration deficits associated with psychosis are independent of diagnosis.Schizophrenia (Heidelberg, Germany) · 2025Article
- Faster bi-stable visual switching in psychosis.Translational psychiatry · 2024Article
- Stronger tilt aftereffects in individuals diagnosed with schizophrenia spectrum disorders but not bipolar disorder.Schizophrenia research · 2024Article
- Representational maps in the brain: concepts, approaches, and applications.Frontiers in cellular neuroscience · 2024Review
- Immersive interfaces for clinical applications: current status and future perspective.Frontiers in neurorobotics · 2024Review
- Self-monitoring in schizophrenia: Weighting exteroceptive visual signals against self-generated vestibular cues.Schizophrenia research. Cognition · 2022Article
- Association of Birth Asphyxia With Regional White Matter Abnormalities Among Patients With Schizophrenia and Bipolar Disorders.JAMA network open · 2021Article
- Postural Control in Childhood: Investigating the Neurodevelopmental Gradient Hypothesis.International journal of environmental research and public health · 2021Article
- Integrated metastate functional connectivity networks predict change in symptom severity in clinical high risk for psychosis.Human brain mapping · 2021Article
- Psychotic Experiences in Schizophrenia and Sensitivity to Sensory Evidence.Schizophrenia bulletin · 2020Article
- A modality-specific dysfunction of pain processing in schizophrenia.Human brain mapping · 2020Article
- Examining motion speed processing in schizophrenia using the flash lag illusion.Schizophrenia research. Cognition · 2020Article
- Deficits in Auditory and Visual Sensory Discrimination Reflect a Genetic Liability for Psychosis and Predict Disruptions in Global Cognitive Functioning.Frontiers in psychiatry · 2020Article
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Visual dysfunction is commonplace in schizophrenia and occurs alongside cognitive, psychotic and affective symptoms of the disorder. Psychophysical evidence suggests that this dysfunction results from impairments in the integration of low-level neural signals into complex cortical representations, which may also be associated with symptom formation. Despite the symptoms of schizophrenia occurring in a range of disorders, the integration deficit has not been tested in broader patient populations. Moreover, it remains unclear whether such deficits generalize across other sensory modalities. The present study assessed patients with a range of psychotic and nonpsychotic disorders and healthy controls on visual contrast detection, visual motion integration, auditory tone detection and auditory tone integration. The sample comprised a total of 249 participants (schizophrenia spectrum disorder n=98; bipolar affective disorder n=35; major depression n=31; other psychiatric conditions n=31; and healthy controls n=54), of whom 178 completed one or more visual task and 71 completed auditory tasks. Compared with healthy controls and nonpsychotic patients, psychotic patients trans-diagnostically were impaired on both visual and auditory integration, but unimpaired in simple visual or auditory detection. Impairment in visual motion integration was correlated with the severity of positive symptoms, and could not be accounted for by a reduction in processing speed, inattention or medication effects. Our results demonstrate that impaired sensory integration is not specific to schizophrenia, as has previously been assumed. Instead, sensory deficits are closely related to the presence of positive symptoms independent of diagnosis. The finding that equivalent integrative sensory processing is impaired in audition is consistent with hypotheses that propose a generalized deficit of neural integration in psychotic disorders.
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