Evidence map›Paper›PMID 28485711›Full record

ArticleeLife2017

MCTP is an ER-resident calcium sensor that stabilizes synaptic transmission and homeostatic plasticity.

Özgür Genç, Dion K Dickman, Wenpei Ma, Amy Tong, Richard D Fetter, Graeme W Davis

Open access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
  2. Genome-Wide Identification of theInternational journal of molecular sciences · 2026
    Article
  3. Review
  4. Physiologic and Nanoscale Distinctions Define Glutamatergic Synapses in Tonic vs Phasic Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  5. Article
  6. Review
  7. Article
  8. IGF-1 receptor regulates upward firing rate homeostasis via the mitochondrial calcium uniporter.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  9. Article
  10. Article
  11. Function of Drosophila Synaptotagmins in membrane trafficking at synapses.Cellular and molecular life sciences : CMLS · 2021
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Özgür GençDepartment of Biochemistry and Biophysics, Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, United States.
Dion K DickmanDepartment of Biochemistry and Biophysics, Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, United States.ORCID 0000-0003-1884-284X
Wenpei MaDepartment of Biological Sciences, University of Southern California, Los Angeles, United States.
Amy TongDepartment of Biochemistry and Biophysics, Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, United States.
Richard D FetterDepartment of Biochemistry and Biophysics, Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, United States.
Graeme W DavisDepartment of Biochemistry and Biophysics, Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, United States.ORCID 0000-0003-1355-8401
University of California, San Francisco · USUniversity of Southern California · US

Funding

Homeostatic Stabilization of Neural Function in Health and DiseaseR35NS097212 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DAVIS, GRAEME W · 2017 to 2024
$9.2M
GENETIC ANALYSIS OF SYNAPTIC HOMEOSTASISR01NS039313 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DAVIS, GRAEME W · 2000 to 2016
$5.3M
Molecular Mechanisms Governing the Homeostatic Control of Synaptic StrengthR01NS091546 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DICKMAN, DION KAI · 2015 to 2024
$4.3M
Dysbindin and the Mechanisms Controlling Homeostatic Synaptic PlasticityR00MH092351 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DICKMAN, DION KAI · 2012 to 2014
$696k
Dysbindin and the Mechanisms Controlling Homeostatic Synaptic PlasticityK99MH092351 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DICKMAN, DION KAI · 2010 to 2011
$175k
NIMH NIH HHS K99 MH092351NIMH NIH HHS R00 MH092351NINDS NIH HHS R01 NS039313NINDS NIH HHS R01 NS091546NINDS NIH HHS R35 NS097212
6 · The paper itself

Abstract

Presynaptic homeostatic plasticity (PHP) controls synaptic transmission in organisms from

Indexed as

Neuronal PlasticitySynaptic TransmissionAnimalsCalciumCell LineDrosophilaNeuronsCalciumbipolarcalcium sensorD. melanogasterendoplasmic reticulumhomeostatic plasticityneurosciencepresynaptic releasesynapse

Identifiers

PMID28485711
PMCPMC5449185
OpenAlexW2613314770

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.