Evidence map›Paper›PMID 28485498›Full record

ArticleJournal of biophotonics2017

Plasmonic nanoparticles-decorated diatomite biosilica: extending the horizon of on-chip chromatography and label-free biosensing.

Xianming Kong, Erwen Li, Kenny Squire, Ye Liu, Bo Wu, Li-Jing Cheng, Alan X Wang

Open access · greenAbstract read
In one paragraph

Article in Journal of biophotonics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Xianming KongSchool of Electrical Engineering and Computer Science, Oregon State University, Corvallis, OR, 97331, USA.
Erwen LiSchool of Electrical Engineering and Computer Science, Oregon State University, Corvallis, OR, 97331, USA.
Kenny SquireSchool of Electrical Engineering and Computer Science, Oregon State University, Corvallis, OR, 97331, USA.
Ye LiuSchool of Electrical Engineering and Computer Science, Oregon State University, Corvallis, OR, 97331, USA.
Bo WuSchool of Electrical Engineering and Computer Science, Oregon State University, Corvallis, OR, 97331, USA.
Li-Jing ChengSchool of Electrical Engineering and Computer Science, Oregon State University, Corvallis, OR, 97331, USA.
Alan X WangSchool of Electrical Engineering and Computer Science, Oregon State University, Corvallis, OR, 97331, USA.
Oregon State University · US

Funding

Toward Point-of-Care Drug Testing: A New Paradigm for On-Chip Chromatography Coupled with Surface-Enhanced Raman ScatteringR21DA043713 · NIDA · OREGON STATE UNIVERSITY · PI WANG, ALAN X · 2017 to 2018
$390k
Dual-Mode Plasmonic Biosensors using Bioenabled NanomaterialsR03EB018893 · NIBIB · OREGON STATE UNIVERSITY · PI WANG, ALAN X · 2015 to 2016
$147k
NIBIB NIH HHS R03 EB018893NIDA NIH HHS R21 DA043713
6 · The paper itself

Abstract

Diatomite consists of fossilized remains of ancient diatoms and is a type of naturally abundant photonic crystal biosilica with multiple unique physical and chemical functionalities. In this paper, we explored the fluidic properties of diatomite as the matrix for on-chip chromatography and, simultaneously, the photonic crystal effects to enhance the plasmonic resonances of metallic nanoparticles for surface-enhanced Raman scattering (SERS) biosensing. The plasmonic nanoparticle-decorated diatomite biosilica provides a lab-on-a-chip capability to separate and detect small molecules from mixture samples with ultra-high detection sensitivity down to 1 ppm. We demonstrate the significant potential for biomedical applications by screening toxins in real biofluid, achieving simultaneous label-free biosensing of phenethylamine and miR21cDNA in human plasma with unprecedented sensitivity and specificity. To the best of our knowledge, this is the first time demonstration to detect target molecules from real biofluids by on-chip chromatography-SERS techniques.

Indexed as

Biosensing TechniquesChromatographyDiatomsGoldHumansMicroRNAsNanoparticlesPhenethylaminesSilicon DioxideSpectrum Analysis, RamanGoldMicroRNAsphenethylaminePhenethylaminesSilicon Dioxidediatomite biosilicalab-on-a-chipon-chip chromatographyphotonic crystalsplasmonicssurface-enhanced raman scattering

Identifiers

PMID28485498
PMCPMC5673565
OpenAlexW2613662381

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.