Evidence map›Paper›PMID 28485127›Full record

ArticleAdvanced healthcare materials2017

Clickable Microgel Scaffolds as Platforms for 3D Cell Encapsulation.

Alexander S Caldwell, Gavin T Campbell, Kelly M T Shekiro, Kristi S Anseth

Abstract read
In one paragraph

Article in Advanced healthcare materials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Light-Gated Amine Exchange in Diarylethene-Crosslinked Microgels.Angewandte Chemie (International ed. in English) · 2025
    Article
  11. Article
  12. Article
  13. Electrostatically Reinforced Double Network Granular Hydrogels.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  14. Review
  15. Article
  16. Article
  17. Granular Hydrogels for Harnessing the Immune Response.Advanced healthcare materials · 2024
    Review
  18. Article
  19. Article
  20. Article

19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alexander S CaldwellDepartment of Chemical and Biological Engineering and the BioFrontiers Institute, University of Colorado Boulder, Jennie Smoly Caruthers Biotechnology Building, 3415 Colorado Ave, Boulder, CO, 80303, USA.
Gavin T CampbellDepartment of Chemical and Biological Engineering and the BioFrontiers Institute, University of Colorado Boulder, Jennie Smoly Caruthers Biotechnology Building, 3415 Colorado Ave, Boulder, CO, 80303, USA.
Kelly M T ShekiroDepartment of Chemical and Biological Engineering and the BioFrontiers Institute, University of Colorado Boulder, Jennie Smoly Caruthers Biotechnology Building, 3415 Colorado Ave, Boulder, CO, 80303, USA.
Kristi S AnsethDepartment of Chemical and Biological Engineering and the BioFrontiers Institute, University of Colorado Boulder, Jennie Smoly Caruthers Biotechnology Building, 3415 Colorado Ave, Boulder, CO, 80303, USA.

Funding

Osteogenic Hydrogel Niches to Promote hMSC Migration and DifferentiationR01DE016523 · NIDCR · UNIVERSITY OF COLORADO AT BOULDER · PI ANSETH, KRISTI S. · 2005 to 2023
$6.2M
Bioactive Hydrogel Niches for 3D VIC CultureR01HL089260 · NHLBI · UNIVERSITY OF COLORADO · PI ANSETH, KRISTI S. · 2008 to 2011
$1.3M
Howard Hughes Medical InstituteNHLBI NIH HHS R01 HL089260NIDCR NIH HHS R01 DE016523
6 · The paper itself

Abstract

While microporous scaffolds are increasingly used for regenerative medicine and tissue repair applications, the most common techniques to fabricate these scaffolds use templating or top-down fabrication approaches. Cytocompatible bottom-up assembly methods afford the opportunity to assemble microporous systems in the presence of cells and create complex polymer-cell composite systems in situ. Here, microgel building blocks with clickable surface groups are synthesized for the bottom-up fabrication of porous cell-laden scaffolds. The facile nature of assembly allows for human mesenchymal stem cells to be incorporated throughout the porous scaffold. Particles are designed with mean diameters of ≈10 and 100 µm, and assembled to create varied microenvironments. The resulting pore sizes and their distribution significantly alter cell morphology and cytoskeletal formation. This microgel-based system provides numerous tunable properties that can be used to control multiple aspects of cellular growth and development, as well as providing the ability to recapitulate various biological interfaces.

Indexed as

Tissue ScaffoldsCapsulesCell ProliferationCells, CulturedCell SurvivalClick ChemistryEquipment DesignEquipment Failure AnalysisHumansHydrogelsMaterials TestingMesenchymal Stem CellsSpheroids, CellularTissue EngineeringCapsulesHydrogelsbottom-up assemblyhMSCshydrogelsmicrogelsmicroporous networks

Identifiers

PMID28485127
PMCPMC5550331

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.