Evidence map›Paper›PMID 28485080›Full record

ReviewJournal of neuroendocrinology2018

PELP1: a key mediator of oestrogen signalling and actions in the brain.

R Thakkar, G R Sareddy, Q Zhang, R Wang, R K Vadlamudi, D Brann

Open access · greenAbstract readReview
In one paragraph

Review in Journal of neuroendocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Altered Expression ofInternational journal of molecular sciences · 2021
    Article
  8. Article
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  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

R ThakkarDepartment of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.ORCID 0000-0002-4480-8859
G R SareddyDepartment of Obstetrics and Gynecology, University of Texas Health Science Center, San Antonio, TX, USA.
Q ZhangDepartment of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.
R WangDepartment of Neurobiology, North China University of Science and Technology, Tangshan, Hebei, China.
R K VadlamudiDepartment of Obstetrics and Gynecology, University of Texas Health Science Center, San Antonio, TX, USA.
D BrannDepartment of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Augusta University · USThe University of Texas Health Science Center at San Antonio · USNorth China University of Science and Technology · CN

Funding

Neuroprotective and Neurogenic Actions of E2 and SERMsR01NS050730 · NINDS · MEDICAL COLLEGE OF GEORGIA (MCG) · PI BRANN, DARRELL W, VADLAMUDI, RATNA K · 2005 to 2014
$3.2M
Brain Aromatase in Neurological Function and DiseaseR01NS088058 · NINDS · AUGUSTA UNIVERSITY · PI BRANN, DARRELL W, VADLAMUDI, RATNA K · 2015 to 2019
$1.8M
NINDS NIH HHS R01 NS050730NINDS NIH HHS R01 NS088058
6 · The paper itself

Abstract

Proline-, glutamic acid- and leucine-rich protein 1 (PELP1) is an oestrogen receptor (ER) coregulator protein identified by our collaborative group. Work from our laboratory and others has shown that PELP1 is a scaffold protein that interacts with ERs and kinase signalling factors, as well as proteins involved in chromatin remodelling and DNA repair. Its role in mediating 17β-oestradiol (E

Indexed as

AnimalsBrainCo-Repressor ProteinsEstrogensMiceMice, KnockoutSignal TransductionTranscription FactorsCo-Repressor ProteinsEstrogensPELP1 protein, humanTranscription FactorsbraincoregulatorneuroprotectionoestrogenPELP1signalling

Identifiers

PMID28485080
PMCPMC5785553
OpenAlexW2612250220

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.